How long rocuronium lasts when given subcutaneously to adult surgical patients

Phase 4

Withdrawn

• Conditions: Anaesthesiology - Anaesthetics; Inadvertent subcutaneous injection of rocuronium

• Registration Number: ACTRN12614001215617
• Lead Sponsor: Fremantle Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-11-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Elective or semi-elective surgery (surgery not required within 24 hours of being booked)
Age 18-64
Expected duration of anaesthesia >6 hours
Planned admission to the intensive care unit after surgery

Exclusion Criteria

Emergency surgery (surgery within 24 hours of procedure being booked)
Patients unable to give informed consent
Severe renal impairment (eGFR <30ml/min)
Significant hepatic impairment (known history of cirrhosis or liver dysfunction)
History of neuromuscular disease (e.g. poliomyelitis, myasthenia gravis, eaton-lambert syndrome)
Patients taking long term medications: lithium, phenytoin, carbamazepine
Administration of other muscle relaxant in previous 24 hours (suxamethonium or other non-depolarising muscle relaxant)
Pregnant or breastfeeding women
Patients requiring muscle relaxation to facilitate surgery
Patients having surgery where muscle relaxation is contraindicated
Significant possibility of anaesthetic ending prior to 6 hours (for instance – intra-abdominal surgery that may be abandoned due to disease progression that can only be decided after starting operation)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of muscle relaxation until train-of-four ratio recovers to 90% as measured by NMT (neuro-muscular transmission) kinemyography monitor[Every 5 minutes during surgery until muscle relaxation resolves]