The Love of Lentils (LoL) Study - Phase 2: The Effect of Acute Consumption of Lentil-containing Food Products on Post-prandial Blood Glucose and Insulin in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Postprandial blood glucose
研究概览
简要总结
This study will recruit 20 healthy adults (male and female) to complete 9 study visits where they will consume different food products (chili, soup and muffin) with or without lentils incorporated into the them. Blood samples will be obtained by finger prick before and for 2 hours after the meal and analyzed for glucose and insulin.
详细描述
The purpose of the current study is to determine the effects of lentil-containing food products on postprandial blood glucose and insulin levels in healthy premenopausal women and men aged 18-40 years old.This study will use a randomized crossover design. Participants will complete a series of 9 study visits during which participants will consume 9 study treatment meals consisting of muffins, soup and chilli, with and without lentils. Participants will then have their blood sampled for the following 2 hours by finger prick. Participants will remain seated during the test period. All study visits will occur at the Human Nutraceutical Research Unit and be separated by a washout period of 3-7 days. Throughout the study, it will be asked that participants' lifestyle and physical activity remain unchanged. Participants will be instructed to not start any new dietary approaches, and to not start any new natural health products (unless instructed by a physician).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women
- •Age 18-40 years (aiming for equal distribution among 18-29, 30-40 years of age)
- •BMI 20-30 kg/m2
排除标准
- •Diabetes (fasting blood glucose ≥7.0 mmol/L and/or 2hr blood glucose >11.1 mmol/L post-75g OGTT) 1
- •Impaired Glucose Tolerance (IGT) (Fasting blood glucose 6.1-6.9 mmol/L and/or 2hr blood glucose 7.8-11.0 mmol/L post-75g OGTT) 1
- •Blood pressure >140/90 mm Hg
- •Any major medical condition including a history of AIDS or hepatitis
- •Medical or surgical event requiring hospitalization within 3 months of randomization
- •Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
- •Natural health products (NHPs) used for glycemic control (all other NHPs okay as long as table for 3 months)
- •Tobacco use
- •Probiotic supplement use
- •Dietary fibre supplement use
- •Pulse consumption >4 servings per week
- •Food allergy or non-food life threatening allergy
- •Alcohol consumption >14 drinks/week or >4 drinks/sitting
- •Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
- •Elite athletes
- •Shift workers
研究组 & 干预措施
Split Red Lentil Muffin
Muffin: 25g available carbohydrate from split red lentil
干预措施: Muffin: 25g available carbohydrate from split red lentil (Other)
Small Green Lentil Muffin
Muffin: 25g available carbohydrate from small green lentil
干预措施: Muffin: 25g available carbohydrate from small green lentil (Other)
Wheat Muffin
Muffin: 25g available carbohydrate from wheat
干预措施: Wheat muffin (Other)
Small Green Lentil Soup
Soup: 25g available carbohydrate from small green lentil
干预措施: Soup: 25g available carbohydrate from small green lentil (Other)
Split Red Lentil Soup
Soup: 25g available carbohydrate from split red lentil
干预措施: Soup: 25g available carbohydrate from split red lentil (Other)
Potato Soup
Soup: 25g available carbohydrate from potato
干预措施: Potato soup (Other)
Small Green Lentil Chili
Chili: 25g available carbohydrate from small green lentil
干预措施: Chili: 25g available carbohydrate from small green lentil (Other)
Split Red Lentil Chili
Chili: 25g available carbohydrate from split red lentil
干预措施: Chili: 25g available carbohydrate from split red lentil (Other)
Rice Chili
Chili: 25g available carbohydrate from rice
干预措施: Rice chili (Other)
结局指标
主要结局
Postprandial blood glucose
时间窗: 2 hours postprandial
Postprandial plasma insulin
时间窗: 2 hours postprandial
次要结局
未报告次要终点
研究者
Alison Duncan
Professor
University of Guelph
