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临床试验/NCT02923089
NCT02923089已完成不适用

The Love of Lentils (LoL) Study - Phase 2: The Effect of Acute Consumption of Lentil-containing Food Products on Post-prandial Blood Glucose and Insulin in Healthy Adults

University of Guelph1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2017年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
24
试验地点
1
主要终点
Postprandial blood glucose

研究概览

简要总结

This study will recruit 20 healthy adults (male and female) to complete 9 study visits where they will consume different food products (chili, soup and muffin) with or without lentils incorporated into the them. Blood samples will be obtained by finger prick before and for 2 hours after the meal and analyzed for glucose and insulin.

详细描述

The purpose of the current study is to determine the effects of lentil-containing food products on postprandial blood glucose and insulin levels in healthy premenopausal women and men aged 18-40 years old.This study will use a randomized crossover design. Participants will complete a series of 9 study visits during which participants will consume 9 study treatment meals consisting of muffins, soup and chilli, with and without lentils. Participants will then have their blood sampled for the following 2 hours by finger prick. Participants will remain seated during the test period. All study visits will occur at the Human Nutraceutical Research Unit and be separated by a washout period of 3-7 days. Throughout the study, it will be asked that participants' lifestyle and physical activity remain unchanged. Participants will be instructed to not start any new dietary approaches, and to not start any new natural health products (unless instructed by a physician).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Healthy men and women
  • •Age 18-40 years (aiming for equal distribution among 18-29, 30-40 years of age)
  • •BMI 20-30 kg/m2

排除标准

  • •Diabetes (fasting blood glucose ≥7.0 mmol/L and/or 2hr blood glucose >11.1 mmol/L post-75g OGTT) 1
  • •Impaired Glucose Tolerance (IGT) (Fasting blood glucose 6.1-6.9 mmol/L and/or 2hr blood glucose 7.8-11.0 mmol/L post-75g OGTT) 1
  • •Blood pressure >140/90 mm Hg
  • •Any major medical condition including a history of AIDS or hepatitis
  • •Medical or surgical event requiring hospitalization within 3 months of randomization
  • •Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
  • •Natural health products (NHPs) used for glycemic control (all other NHPs okay as long as table for 3 months)
  • •Tobacco use
  • •Probiotic supplement use
  • •Dietary fibre supplement use
  • •Pulse consumption >4 servings per week
  • •Food allergy or non-food life threatening allergy
  • •Alcohol consumption >14 drinks/week or >4 drinks/sitting
  • •Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
  • •Elite athletes
  • •Shift workers

研究组 & 干预措施

Split Red Lentil Muffin

Experimental

Muffin: 25g available carbohydrate from split red lentil

干预措施: Muffin: 25g available carbohydrate from split red lentil (Other)

Small Green Lentil Muffin

Experimental

Muffin: 25g available carbohydrate from small green lentil

干预措施: Muffin: 25g available carbohydrate from small green lentil (Other)

Wheat Muffin

Placebo Comparator

Muffin: 25g available carbohydrate from wheat

干预措施: Wheat muffin (Other)

Small Green Lentil Soup

Experimental

Soup: 25g available carbohydrate from small green lentil

干预措施: Soup: 25g available carbohydrate from small green lentil (Other)

Split Red Lentil Soup

Experimental

Soup: 25g available carbohydrate from split red lentil

干预措施: Soup: 25g available carbohydrate from split red lentil (Other)

Potato Soup

Placebo Comparator

Soup: 25g available carbohydrate from potato

干预措施: Potato soup (Other)

Small Green Lentil Chili

Experimental

Chili: 25g available carbohydrate from small green lentil

干预措施: Chili: 25g available carbohydrate from small green lentil (Other)

Split Red Lentil Chili

Experimental

Chili: 25g available carbohydrate from split red lentil

干预措施: Chili: 25g available carbohydrate from split red lentil (Other)

Rice Chili

Placebo Comparator

Chili: 25g available carbohydrate from rice

干预措施: Rice chili (Other)

结局指标

主要结局

Postprandial blood glucose

时间窗: 2 hours postprandial

Postprandial plasma insulin

时间窗: 2 hours postprandial

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alison Duncan

Professor

University of Guelph

研究点 (1)

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