Concurrent Multiparameter Optimized Noninvasive Brain Stimulation for Working Memory in Aging

Medical University of South Carolina0 个研究点目标入组 25 人2026年12月31日

适应症Healthy Aging

干预措施Transcranial electrical stimulation

概览

阶段: 不适用
干预措施: Transcranial electrical stimulation
疾病 / 适应症: Healthy Aging
发起方: Medical University of South Carolina
入组人数: 25
主要终点: Electrocortical EEG changes pre- to post-tES
状态: 撤回
最后更新: 2个月前

概览研究者入排标准研究组 & 干预措施结局指标相似试验

概览

简要总结

With an aging population worldwide, it is critical to develop effective interventions promoting healthy cognitive aging. Transcranial electrical stimulation (tES) is a promising but not fully realized noninvasive brain stimulation approach that could improve memory. This study investigates the behavioral and electrocortical effects of personalized tES in aging to determine whether whether optimal dosing, electrode placements, and waveforms elicit stronger responses.

详细描述

With an aging population worldwide, it is critical to develop effective interventions promoting healthy cognitive aging. A key component of healthy cognition is intact working memory, an executive neural process holding information temporarily. With increasing age, working memory capacity decreases and is associated with a loss of independence, thus incentivizing the need to retain a healthy working memory capacity. In addition to facilitating healthy aging, developing a method that improves working memory could help those diagnosed with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), which is currently is the 6th leading cause of death in the US and has an annual economic burden of $305 billion. A potential approach to improve working memory is transcranial electrical stimulation (tES), a noninvasive brain stimulation method using scalp electrodes to deliver low electrical currents of 2 milliamps (mA) over the cortical target. While some prior studies have shown that prefrontal tES can improve working memory in older adults, there are small meta-analytic effect sizes and no FDA-approved indications to date. These mixed results could be due to applying one-size-fits-all and suboptimal tES parameters. In this study, the investigators will test the effects of personalized parameters, including dosing, electrode positioning, and waveforms compared to standard tES and placebo.

注册库

clinicaltrials.gov

开始日期

2026年12月31日

结束日期

2027年12月31日

最后更新

2个月前

研究类型

Interventional

研究设计

Crossover

性别

All

研究者

发起方

Medical University of South Carolina

责任方

Principal Investigator

主要研究者

Kevin Caulfield

Assistant Professor

Medical University of South Carolina

入排标准

入选标准

•50 - 85 y.o.
•Endorse good health with no history of mental or physical illness
•Willingness to adhere to the study schedule and assessments
•Able to read consent document and provide informed consent.
•English is a first or primary fluent language.

排除标准

•Any current psychiatric diagnosis or current Clinical Global Impression ratings of psychiatric illness \> 1
•Neurodevelopmental disorders, history of Central Nervous System (CNS) disease, concussion, overnight hospitalization, or other neurologic sequela, tumors, seizures, meningitis, encephalitis, or abnormal CT or MRI of the brain
•Any psychotropic medication is taken within 5 half-lives of procedure time
•Any head trauma resulting in loss of consciousness
•Visual impairment (except the use of glasses)
•Inability to complete cognitive testing
•Active participation or plan for enrollment in another evidence-based clinical trial affecting the psychosocial function
•Repeated abuse or dependence upon drugs (excluding nicotine and caffeine) or taking medications including stimulants, modafinil, thyroid medication, or steroids
•Implanted devices/ferrous metal of any kind
•History of seizure or epilepsy, currently taking medications that lower seizure thresholds