Effect of resistance training on Klotho and arterial stiffness in chronic kidney disease
Phase 3
- Conditions
- Chronic kidney patients (CKD).Chronic kidney disease (CKD)
- Registration Number
- IRCT20240107060639N1
- Lead Sponsor
- Shahrood University of Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
In stage 3 to 5 of ckd disease, it means that their blood creatinine is higher than 1.5.
Body mass index should be less than 40
Systolic blood pressure should be less than 18 and diastole less than 10
Have the ability to perform movement
Exclusion Criteria
Use of immunosuppressive drugs
Smoking and tobacco use
Having hypothyroidism and hyperthyroidism
History of heart attack and stroke
Congenital kidney disease
Have regular physical activities
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Central arterial stiffness with Cardio-ankle vascular index (CAVI). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: Arterial stiffness was measured by oscillometric method using VaSera VS-2000 (Fukuda Denshi, Tokyo, Japan).;Peripheral arterial stiffness with ankle-brachial index (ABI). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: ankle-brachial index was measured by oscillometric method using VaSera VS-2000 (Fukuda Denshi, Tokyo, Japan).;Blood plasma klotho levels. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.
- Secondary Outcome Measures
Name Time Method Maximum muscle strength (upper body and lower body). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: Using the maximum repetition method.;Product of calcium and phosphorus. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.;Vitamin D levels. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.;Serum creatinine. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.