the effect of vitamin K supplementation on bone factors in hemodialysis patients

Phase 2

Conditions: Patients with ESRD undergoing hemodialysis.
Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease
I12.0

Registration Number: IRCT20221217056845N1

Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 72

Inclusion Criteria

Not using anticoagulant drugs
age 18-75 years
patient with ESRD and hemodialysis
patients that dialyses > 1 months.

Exclusion Criteria

Coagulation disorder
Lack of consent to study
Hypocalcemia or hypercalcemia in patients
Infection before and during treatment with High CRP
Using of antibiotic drugs
Using of osteoporosis drugs
lack of medication compliance

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of the average serum levels of albumin after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of calcium after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of phosphorus after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the average serum levels of Vitamin D after the implementation of the intervention. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.

Secondary Outcome Measures

Name	Time	Method
Comparison of the mean serum PTH level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.;Comparison of the mean serum alkaline phosphatase (AKP) level after the implementation of the intervention to the basic value. Timepoint: At the beginning of the study and 3 month later. Method of measurement: blood sample.