NCT03939325Unknown不适用
Impact of Different Shock Wave Release Frequencies on Disintegration of Renal Stones in Assuit Urology & Nephrology University Hospital
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 主要终点
- stone free rate
研究概览
简要总结
The impact of different frequencies on pattern of disintegration of renal stones
详细描述
- Prior to the introduction of extracorporeal shockwave lithotripsy (ESWL) in 1980, the only treatment available for calculi that could not pass through the urinary tract was open surgery. Since then, ESWL has become the preferred tool in the urologist's armamentarium for the treatment of renal stones, , ESWL is minimally invasive, exposes patients to less anaesthesia, and yields equivalent stone-free rates in appropriately selected patients.
- The efficacy of ESWL lies in its ability to pulverize calculi in vivo into smaller fragments, which the body can then expulse spontaneously. Shockwaves are generated and then focused onto a point within the body. The shockwaves propagate through the body with negligible dissipation of energy (and therefore damage) owing to the minimal difference in density of the soft tissues. At the stone-fluid interface, the relatively large difference in density, coupled with the concentration of multiple shockwaves in a small area, produces a large dissipation of energy. Via various mechanisms, this energy is then able to overcome the tensile strength of the calculi, leading to fragmentation. Repetition of this process eventually leads to pulverization of the calculi into small fragments that the body can pass spontaneously and painlessly.
- It is well recognized that the popularity of extracorporeal shock wave lithotripsy (SWL), despite its non-invasive character, has decreased during recent years. This is partly explained by the technological achievements in endoscopy and urologists' enthusiasm for such procedures. Another explanation is that many urologists have been insufficiently successful with SWL. The latter effect might to some extent be a result of the performance of the lithotripter used, but in too many cases, it is evident that the principles of how shock wave lithotripsy should be carried out are poorly appliedical aspect
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pelvic and upper ureteric stones
- •Stone size less than 2 cm
- •Stone density up to 1000 HU
排除标准
- •Lower calycle stone
- •Stone size 2 cm or more
- •Stone denstiy more than 1000
- •age group less than 18 y
- •uncontrolled hypertension patient and bleeding disorder
- •Pregnancy
- •Patients with UPJ obstruction, ureteral strictures,
- •Congenital anomalies
- •Previous stented ureter
- •Narrow neck of the calycx less than 30 %
结局指标
主要结局
stone free rate
时间窗: 2 weeks
complete disintegration of renal stones or having clinically insignificant gravel smaller than 2 mm
次要结局
未报告次要终点
研究者
Mohamed Ahmed Mohamed El Taher
M.B.B.CH
Assiut University
相似试验
Unknown
不适用
Predictors of Pain Relief in Chronic Pancreatitis Undergoing ESWLChronic PancreatitisNCT04490083Asian Institute of Gastroenterology, India80
已完成
不适用
Escalating, Constant and Reduction Energy Output in SWL for Renal StonesRenal StonesNCT02037906Princess Al-Johara Al-Ibrahim Cancer Research Center150
尚未招募
早期 1 期
Extra-Corporeal Shock Wave Lithotripsy for Renal and Upper Ureteral Stones in Adults Under Locally Infiltrate d Anaesthetics ; a Clinical Randomized Controlled StudyStone UreterNCT06462573Assiut University60
Unknown
不适用
Shockwave Lithotripsy (SWL) Under Selective, General Anesthesia.Renal CalculiUreteral CalculiNCT01008267Assaf-Harofeh Medical Center60
尚未招募
不适用
Treatment of 1-2cm renal stones: a pilot randomised trial comparing shock wave lithotripsy, ureterorenoscopic stone removal and percutaneous nephrolithotomy.ACTRN12614000688684Monash Health60