Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Nutritional deficiencies
研究概览
简要总结
The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE).
The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •people over 6 years old
- •people with Primary Failure Eruption
排除标准
- •children under 6 years old
- •endocrine pathology that may interfere with dental eruption
- •chemotherapy / radiotherapy
- •bisphosphonate treatment
结局指标
主要结局
Nutritional deficiencies
时间窗: at inclusion (day 1)
nutritional deficiencies assessed by a questionnaire
Chewing
时间窗: at inclusion (day 1)
Assessment of chewing by Plana's Functional Masticatory Angles (PFMA)
Nasal breathing
时间窗: at inclusion (day 1)
Assessment of nasal breathing by the Rosenthal's test
Number of teeth
时间窗: at inclusion (day 1)
number of teeth
Recording of dental caries
时间窗: at inclusion (day 1)
recording of dental caries by Decayed Missing Filled Teeth index (DMFT index)
Recording the location of dental caries
时间窗: at inclusion (day 1)
the number of teeth affected using the international classification index
Drugs intra uterine exposure
时间窗: at inclusion (day 1)
drugs during pregnancy
Periodontium
时间窗: at inclusion (day 1)
assessment of the periodontium by Maynard and Wilson classification
Oral hygiene
时间窗: at inclusion (day 1)
assesment of oral hygiene by plaque index (Löe and Silness, 1963)
Profile (shape)
时间窗: at inclusion (day 1)
assessment of the profile (shape)
Smile
时间窗: at inclusion (day 1)
morphology of the smile
Gingival inflammation
时间窗: at inclusion (day 1)
assesment of gingival inflammation by gingival index (Löe and Silness, 1963)
Treatment needs
时间窗: at inclusion (day 1)
assessment of treatment needs using Community Periodontal Index of treatment Needs (CPITN)
Face shape
时间窗: at inclusion (day 1)
assesment of the face shape : round, square, oval
Symmetry of the face
时间窗: at inclusion (day 1)
symmetry of the face (yes/no)
Vertical dimension
时间窗: at inclusion (day 1)
assessment of the vertical dimension: anterior infraclusion or overbite (in %)
Transversal dimension
时间窗: at inclusion (day 1)
assessment of the transversal dimension: posterior transversal dimension (in mm)
Sagittal dimension
时间窗: at inclusion (day 1)
Assessment of the sagittal dimension by Angle's classification
Swallowing
时间窗: at inclusion (day 1)
Assessment of swallowing by lingual interposition
次要结局
- Type of treatment performed(at inclusion (day 1))
- Mutations causing PFE(at inclusion (day 1))