Sleep-disordered Breathing After Solid Organ Transplantation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Transplantation
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- Number of participants with SDB and type (central or obstructive) of SDB
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a person's ability to function and reduces quality of life. Transplantation has become an important treatment modality for end-stage organ failure. Transplant recipients are now living longer and, hence, develop chronic adverse medical conditions. Furthermore, transplantation is associated with weight gain. Despite the high prevalence of poor sleep and cardiovascular conditions among transplant patients, SDB is not well studied in these patients.
Detailed Description
The primary research objective is to evaluate the prevalence, incidence and type (central or obstructive) of SDB in patients after lung transplantation. Secondary research objectives are the evaluation of correlations between severity of SDB and clinical findings (weight, medical therapy, heart function, lung function, renal function, graft failure, ...). Furthermore, the investigators will evaluate the relationship between SDB and cardiovascular morbidity.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients 1 year after lung transplantation
Exclusion Criteria
- •Refusal of PSG
- •Medical contra-indication to perform PSG
Outcomes
Primary Outcomes
Number of participants with SDB and type (central or obstructive) of SDB
Time Frame: 1 year after lung transplantation
Prevalence of different types of SDB after lung transplantation
Secondary Outcomes
- Lung function measurement(1 year after lung transplantation)
- Blood analysis(1 year after lung transplantation)
- 24h blood pressure(1 year after lung transplantation)
- Echocardiography(1 year after lung transplantation)