Chitosan Versus Glucosamine Phonophoresis in the Management of Knee Osteoarthritis: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Range of Motion at knee joint both in extension and flexion
研究概览
简要总结
The study will be conducted to answer the following questions:
- Is there an effect of phonophoresis using glucosamine on pain level , function and range of motion in knee osteoarthritis patients ?
- Is there an effect of phonophoresis using chitosan on pain level , function and range of motion in knee osteoarthritis patients ?
- Is there a difference between the effect of phonophoresis using glucosamine and phonophoresis using chitosan on pain level , function and range of motion in knee osteoarthritis patients ?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •unilateral or bilateral grade II knee osteoarthritis (clinical and imaging diagnosis X-ray).
- •knee pain intensity ≥ 5 on the Visual Analogue Scale (VAS)
排除标准
- •Anterior Cruciate Ligament (ACL) and meniscus injury
- •use of oral or injected corticosteroids in the last 3 months
- •history of knee surgery or fracture
- •acute infectious synovitis or arthritis conditions
- •presence of malignancy
- •individuals with, topical lesions, contact dermatitis and history of cutaneous hypersensitivity
结局指标
主要结局
Range of Motion at knee joint both in extension and flexion
时间窗: Baseline and Change from baseline scores at four weeks
The ROM will be measured using the Baseline 12-1056 bubble inclinometer. Patients will be in prone position and will be instructed to move their leg away from the thigh to measure extension range of motion and move the leg toward the thigh to measure flexion
Change in Visual Analog Scale
时间窗: Baseline and Change from baseline pain scores at four weeks
The visual analog scale (VAS) is a pain rating scale first used by Hayes and Patterson in 1921. Scores are based on self-reported measures of symptoms that are recorded with a single handwritten mark placed at one point along the length of a 10-cm line that represents a continuum between the two ends of the scale-"no pain" on the left end (0 cm) of the scale and the "worst pain" on the right end of the scale (10 cm).
Change in WOMAC INDEX
时间窗: Baseline and Change from baseline scores at four weeks
The WOMAC VA 3.1 Index score (WOMAC INDEX) is the sum of WOMAC A (total pain), WOMAC B (stiffness) and WOMAC C (functional impairment) subscores. The WOMAC INDEX score ranges from 0 to 2400 mm, with higher scores indicating higher disease burden.
次要结局
未报告次要终点
研究者
Mohamed Magdy Ali Hassan ElMeligie
Principal investigator
October 6 University