Phase II study of efficiency of peripheral blood stem cell harvest in POEMS syndrome patients with low-dose cyclophosphamide plus G-CSF
Phase 2
- Conditions
- POEMS syndrome
- Registration Number
- JPRN-UMIN000018385
- Lead Sponsor
- Chiba University Hospital Department of Hematology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with plasma cells in CBC 2) Pregnant or nursing women. Patients reuse to contraception during examination period 3) Patients have active other malignant diseases including simultaneous cancer and disease free state within 5 years after treatment for other cancer except curable intramural cancer by local treatment. 4) Patients with serious mental disorders 5) Patients with HBs antigen-positive 6) Patients with HIV antibody-positive 7) Patients with a history of severe allergy to the drugs 8) Patients with serious active infection 9) Patients who are determined to be inappropriate for this study by physicians
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients collecting >= 2*10^6 CD34+ cells/kg on day 1 (%)
- Secondary Outcome Measures
Name Time Method Safety Effect of this regimen on engraftment Incidence of adverse events (Grade 3) The day of first apheresis