Cytotoxic T-cell exhaustion before and after twelve weeks trial of antidepressant treatment in first-onset major depressive disorder
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- PD-1 cell counts
研究概览
简要总结
Major depressive disorder is a mood disorder with variable severity
The pathophysiology of depression has not yet been clearly defined
Various hypotheses stated that various neurochemical changes happen in the brain during depression
These substances might influence the immune system
Both humoral and cell-mediated immunity are altered in depression
As Major depressive disorder is a chronic stressful state the T Cells get exhausted
The exhaustion is mediated by various proteins like Programmed cell death protein PD 1 and Cytotoxic T Lymphocyte antigen CTLA 4
Exhaustion of these cytotoxic T lymphocytes leads to depressed cell mediated immunity by decreased production of cytokines like TNF alpha and IFN gamma
The diagnostic prognostic and predictive role in the therapeutic outcome of T cell exhaustion has not yet been clearly explored
Hence the present study is designed to explore the above mentioned aspects
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •The patients of either gender aged between 18-60 years, who will attend psychiatry OPD or be admitted to psychiatry IPD with the diagnosis of first onset major depressive disorder (MDD) without psychotic symptoms according to ICD-11 criteria will be selected as MDD cases.
排除标准
- •Any other psychiatric disorder
- •Substance use
- •Acute and chronic major physical illness
- •Any chronic medications except iron with folic acid and calcium with vitamin D supplementation
- •History of any infection during the last 6 weeks.
- •Electroconvulsive therapy or any other neuromodulation.
结局指标
主要结局
PD-1 cell counts
时间窗: ONE YEAR
次要结局
- CTLA 4 CELL COUNTS(TNF- ALPHA, IFN-GAMMA)
研究者
Dr Shanty G Raj
Delhi university