Association of Body Weight Growth After Birth and Bronchopulmonary Dysplasia(BPD)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- the incidence of BPD
研究概览
简要总结
Bronchopulmonary dysplasia (BPD) is one of the most common, complex, and severe diseases in preterm infants. BPD was first described as chronic pulmonary disease in survivors of severe respiratory distress syndrome (RDS) in 1967, which was also called as the "old" BPD. In recent years, the definition for BPD has developed a lot. The National Institute of Child Health and Human Development (NICHD) workshop in 2018 assessed BPD at 36 post-menstrual age (PMA) along with radiographic confirmation and used a severity grading of I-III. Although with effective surfactant supplement and oxygen support, BPD brings a great challenge to neonatologists.
详细描述
Besides persistent inflammation, prolonged invasive ventilation and oxidative damage. body weight is the one of the most important factors to induce BPD. Poor extrauterine growth is commonly described in extremely preterm infants. But, the relationship of postnatal growth with BPD and respiratory morbidity is not entirely understood.
The aim of the present study is to assess whether body weight growth after birth is the risk factor for BPD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Minute 至 1 Day（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •equal to or less than 32 weeks' gestational age
排除标准
- •main congenital malformation
- •parents' refusal
结局指标
主要结局
the incidence of BPD
时间窗: up to 36 weeks' gestational age
the infant was diagnosed with BPD
次要结局
- body weight growth after birth(up to 36 weeks' gestational age)
研究者
Chen Long,MD
director
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University