Exploring biomarkers in pediatric psoriasis: non-invasive measurement by Transdermal Analyses Patches

Completed

Conditions: Chronic skin disease
10014982
Psoriasis

Registration Number: NL-OMON45371

Lead Sponsor: Dermatologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 42

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
Age< 18 years
Willing to sign the informed consent
Diagnosis of psoriasis according to a dermatologist.
On topical treatment and no history of systemic treatment (mild, for group A)
On systemic treatment (severe, group B)

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:;Not enough psoriasis plaques to apply the TAPs
Not willing to apply the TAPs or sign informed consent

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoints are the levels of cytokines measured on the skin<br /><br>surface using FibroTx TAP. Levels of cytokines are compared between<br /><br>lesional, perilesonal and non-involved skin, as well as between children and<br /><br>adolescents with mild and severe psoriasis and followed over time. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Levels of cytokines correlated to the clinical outcome (PASI) in time. The VAS<br /><br>score, in order to evaluate the possible discomfort and perception of the<br /><br>children by the removal of the small plasters. </p><br>