Effects of Transcranial Temporal Interference Stimulation on Risky Decision-making and Impulse Control in Gambling Disorder
- Conditions
- Gambling Disorder
- Interventions
- Device: tTIS on dACC, theta frequency (5 Hz)Device: tTIS on dACC, High frequency
- Registration Number
- NCT06467422
- Lead Sponsor
- Shanghai Mental Health Center
- Brief Summary
The purpose of this research is to investigate the effect of transcranial temporal interference stimulation (tTIS) targeting the dorsal anterior cingulate cortex in patients with gambling disorder.
- Detailed Description
This study will apply the emerging non-invasive deep brain stimulation of tTIS to the dorsal anterior cingulate cortex in a randomized, double-blind design to demonstrate the possibility of non-invasively targeting the anterior cingulate cortex to modulate impulse control and risky decision-making without activating other regions below the electrodes. Additionally, this study will combine the fMRI recordings to describe local and network effects on brain activity. Specifically, each participant will be assessed at baseline with a scale and T1WI sequence and diffusion tensor imaging, and will randomly receive a combination of stimulation sequentially during the intervention phase, with more than a one-week interval ensuring that there is no interference between each of the two stimulation sequences.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Male
- Target Recruitment
- 30
- Aged 18-60, male or female, right handed;
- With 9 or more years of education, and able to cooperate in completing the questionnaire assessment and behavioural tests.
- Meets the DSM-5 diagnostic criteria for gambling addiction;
- Previous gambling behaviour of not less than 1 year's duration (at least one gambling session per week or more);
- Normal or corrected normal vision and hearing;
- Agrees to cooperate in completing the follow-up assessment;
- No history of neurological problems or head injury; and no skin sensitivity.
- Agree to cooperate in completing the follow-up assessment;
- No metal implantation in the head, no history of neurological problems or head injury, and no skin sensitivity.
- Suffering from severe cognitive dysfunction, such as a history of head trauma, cerebrovascular disease, epilepsy, etc., use of cognitive-promoting medications in the last 6 months;
- Other psychoactive substance abuse or dependence in the last 5 years (except nicotine).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Theta Stimulation(6Hz, generated with electrodes of 2kHz and 2.005kHz) tTIS on dACC, theta frequency (5 Hz) Session1#T1(10min)+DTI(15min) Session2#rsfMRI(8min)+rsfMRI-Theta tTIs(8min)+rsfMRI(8min)+TASK fMRI-Theta TI(20min) High Frequency Stimulation(generated with two electrodes of 2kHz) tTIS on dACC, High frequency Session1#T1(10min)+DTI(15min) Session2#rsfMRI(8min)+rsfMRI-HF tTIs(8min)+rsfMRI(8min)+TASK fMRI-HF TI(20min)
- Primary Outcome Measures
Name Time Method Activation of dACC Through the fMRI procedure Activation of dACC is measured with resting-state fMRI and task fMRI.
Activation of decision-making network Through the fMRI procedure Activation of decision-making network is measured with resting-state fMRI and task fMRI connectivity analysis.
The change of impulsivity Through the last 20 minutes of the fMRI session. The change of impulsivity will be measured by sequential decision-making task.
- Secondary Outcome Measures
Name Time Method The change of gambling craving 8 minutes, 16 minutes, 24 minutes, 44 minutes of the fMRI session. Gambling craving will be measured by the gambling craving Visual Analog Scale (VAS). The total score of VAS ranged from 0 to 10, in which higher scores mean a higher level of gambling craving.
Trial Locations
- Locations (1)
Shanghai Mental Health Center
🇨🇳Shanghai, Shanghai, China