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Clinical Trials/NCT05721274
NCT05721274
Completed
Not Applicable

The Last Mile - Community Engagement and Conditional Incentives to Accelerate Polio Eradication in Conflict-affected Areas of Pakistan

Aga Khan University1 site in 1 country840 target enrollmentDecember 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Polio
Sponsor
Aga Khan University
Enrollment
840
Locations
1
Primary Endpoint
Fully Immunized Children
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

Immunization is one of the most cost-effective and successful public health strategy in reducing the health, economic and societal burden of many infectious diseases. Pakistan and Afghanistan remain the only countries where polio is endemic, and Pakistan reports the most cases in the world. Although the rate is lower than in previous years, the situation remains alarming. This study objective is to decrease polio vaccine refusals and zero-dose vaccines by motivating behaviour change

Detailed Description

Study Design:The study will adopt a pretest/post-test quasi-experimental approach with two intervention UCs and two control UCs. For each target, intervention SHRUC, a separate, matched control SHRUC of comparable size and location will be identified for eventual pre-post comparison. Children under-five will be eligible for inclusion. Intervention: The intervention package will include community mobilization and incentivization. Clusters will be formed on a population of 2000-2500 in each intervention UC, thus approximately ten clusters in each. Project will form or liaise with community groups or committees (male and female) in each cluster, which are already operational in many parts of the target UCs. However, to focus on reducing polio vaccine refusals, our program will adopt a unique incentivization approach, preceded by trust-building community mobilization. Clusters will be determined based on the existing micro plans of the PPEP. Microplans are a population-based set of components, at UC-level, used by the program for delivering polio vaccination efficiently. Baseline and end-line surveys will be conducted in the target and control UCs. Study Site: The study will be conduucted in district Karachi, Sindh and other in district Bannu, KP. Intervention UCs: Haji Mureed Goth Karchi and Mira-Khel KP COntrol UCs : Nazivmabad UC 49 Karachi and Khwajamad- Bannu) The research team will engage with multiple village/mohalla committees in the intervention UCs to address and eliminate misconceptions about polio. One-to-one meetings and group sessions which will be led by the committee members, to provide messages on childhood immunization with project-specific IEC material, will be held in each targeted cluster. These platforms would be helpful to identify and counsel their underlying fears and socio-psychological factors about the vaccines, such as painful neonatal experiences, mishandling, doubts, fear of vaccine-related side effects, distrust, etc. The community-based incentives will be conditional based on the decrease in vaccine refusal rates within stipulated time. Communities successful in achieving these targets will be rewarded incentives to improve their infrastructure, including sanitation and hygiene, and water resources.

Registry
clinicaltrials.gov
Start Date
December 1, 2022
End Date
March 31, 2024
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Dr Jai Kumar Das

Assistant Professor and Assistant Director

Aga Khan University

Eligibility Criteria

Inclusion Criteria

  • Household with at least one child 0-59 months of age

Exclusion Criteria

  • Thise not willing to participate in study

Outcomes

Primary Outcomes

Fully Immunized Children

Time Frame: at 9 months

This would be children who are fully vaccinated appropriate to the age

Vaccine refusals

Time Frame: at 9 months

Number of polio vaccine refusals in polio campaign

IPV coverage

Time Frame: at 9 months

this would be injectable polio vaccine coverage in children below five years of age

Study Sites (1)

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