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Patient age 18 -60 years.Non contributory medical history (ASA1),Deep caries extending to pulp chamber.Vital mature first mandibular molar with symptoms of irreversible pulpitis.Tooth with positive response to pulp sensibility testing. Clinical diagnosis of irreversible pulpitis with PAI score=2.Tooth should be restorable.Tooth with probing pocket depth and mobility should be within normal limits.

Exclusion Criteria

Teeth with immature roots.Teeth with clinical sign of pulp necrosis such as swelling or presence of sinus tract .Teeth with prominent radiolucency in the furcation area, presence of internal or external root resorption, any calcification.Teeth with no evidence of bleeding after communication with pulp chamber. Absence of antagonist tooth.

Had taken analgesic in past 3 days or antibiotic in past one month.Tooth with periapical lesion visible on radiograph. Teeth in which hemostasis was not achieved in 10 min.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
primary outcome : evaluate change in inflammatory marker before and after pulpotomy <br/ ><br>Timepoint: 7 days

Secondary Outcome Measures

Name	Time	Method
secondary Outcome assessment criteria to be performed every 3, 6 and 12 months : <br/ ><br> Clinical criteria: <br/ ><br>1.Post operative pain assessment using VAS after 24, 48, 72 hours and 7 days. <br/ ><br>2.No history of spontaneous pain or discomfort except for the first 2 days after treatment <br/ ><br>3.No tenderness to palpation or percussion and the tooth is functional <br/ ><br>4.Normal mobility and probing pocket depth <br/ ><br>5.Soft tissues around the tooth are normal with no swelling or sinus tract <br/ ><br> <br/ ><br>Radiographic criteria: <br/ ><br>1. No pathosis evident on the radiograph such as periapucal widening, root resorption, furcal pathosis or new periapical pathosis . <br/ ><br>Timepoint: 12 months