Inhibition of the Endogenous GIP Response With a GIP Receptor Antagonist
- Conditions
- Glucose Metabolism Disorders
- Registration Number
- NCT03133741
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Brief Summary
Delinieation of GIP's effects during an oral glucose tolerance test (OGTT) in humans using GIP receptor antagonisation.
- Detailed Description
Aim: To evaluate the role of GIPR signalling in postprandial physiology, including bone and glucose homeostasis, using a naturally occurring GIP fragment (GIP-A), which antagonises the GIPR.
Eighteen healthy men (age 18-70 years, BMI 19-35 kg/m2) with normal kidney and liver parameters and haemoglobin levels and no first-degree relatives with type 2 diabetes will be included in a randomised, double-blinded, placebo-controlled cross-over study. Study consists of four study days with concomitant infusions of A) GIP-A, B) GLP-1 receptor antagonist Exendin\[9-39\], C) GIP-A + Exendin\[9-39\], or D) saline (placebo).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 18
- Normal kidney function, liver function and hemoglobin levels.
- Medication, Diabetes type 1 or 2, first degree relatives with Diabetes type 2
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Insulin levels 240 minutes Serum insulin AUC (area under the curve)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Center for Diabetes Research
🇩🇰Gentofte, Copenhagen, Denmark
Center for Diabetes Research🇩🇰Gentofte, Copenhagen, Denmark