Impact of microbial communities on obesity

Recruiting

• Conditions: corpulence; obesity; 10000546

• Registration Number: NL-OMON31153
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

-Subjects must be able to understand the written study information and must be able to sign an informed consent
-Twin living separately for more than 5 years
-twin pairs who will differ more than 5 kg/m2 in Body Mass Index (BMI)
-Twin pairs who will have a similar BMI
-Where possible a sibling, not older/younger than 5 years than the twin, will be included

Exclusion Criteria

Recent history (i.e. last month) or current use of medication that may affect the intestinal microbiota.
-Use of pre- and/or probiotics (for at least one month before collection of the fecal samples).
-Pre-exiting bowel diseases
-Pregnancy/breast feeding

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>From 40 monozygotic twin pairs the bacterial composition of their fecal<br /><br>microbiota, their weigth, length and BMI will be determined. Within each pair<br /><br>comparisons between the microbiotas will be made at different taxonomic levels.<br /><br>These pair-wise comparisons will determine if significant differences exists<br /><br>between pairs with different bmi compared to those having a similar bmi.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable: 0</p><br>