Personalized Treatment for Patients With Premature Ventricular Beats

Recruiting

• Conditions: Ventricular Premature Complexes

• Registration Number: NCT04617717
• Lead Sponsor: Oslo University Hospital

Brief Summary

Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?

Detailed Description

Not available

Study Timeline

• Study Start: 2020-09-30
• Study First Submitted: 2020-10-26
• Study First Submitted QC: 2020-10-30
• Study First Posted: 2020-11-05
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-31
• Last Update Posted: 2023-11-02
• Primary Completion: 2024-06-30
• Study Completion: 2040-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

Patients referred for PVC ablation

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MRI-based evidence of structural heart disease	3-5 years	Evidence of structural heart disease from MRI compared to echocardiography
PVC induction vs PVC/HR-relationship	3-5 years	Correlation of method for induction of PVCs during invasive procedure vs PVC/HR relationship during CPET
EPS-based evidence of structural heart disease	3-5 years	Evidence of structural heart disease from invasive electrophysiology vs MRI and echo

Trial Locations

Locations (1)

Oslo University Hospital; 🇳🇴 Oslo, Norway