Proteiomic Fingerprints of Gastric Juice

Not Applicable

Completed

• Conditions: Gastric Cancer
• Interventions: Other: normal subject; Other: gastric cancer

• Registration Number: NCT00834236
• Lead Sponsor: Kaohsiung Veterans General Hospital.

Brief Summary

No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric juice. The aim of this study was to develop a novel non-invasive modality for detecting gastric cancer by measurement of biomarkers in gastric juice.

Detailed Description

Patients and methods: The study consisted of two parts: (1) investigating the differences in gastric juice biomarker concentrations between gastric cancer patients and controls, and (2) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for biomarker concentration.

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2009-02-02
• Study First Submitted QC: 2009-02-02
• Study First Posted: 2009-02-03
• Primary Completion: 2011-03
• Study Completion: 2011-03
• Status Verified: 2015-09
• Results First Submitted: 2015-09-30
• Results First Submitted QC: 2015-11-03
• Last Update Submitted: 2015-11-03
• Results First Posted: 2015-12-07
• Last Update Posted: 2015-12-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• healthy subjects and gastric cancer patients documented by endoscopy.

Exclusion Criteria

• the use of proton pump inhibitors or histamine-2 receptor antagonists within 4 weeks prior to the study
• coexistence of two kinds of gastroduodenal lesions
• coexistence of severe systemic diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
gastric cancer	normal subject	gastric cancer patients
normal subject	normal subject	healthy subject
normal subject	gastric cancer	healthy subject
gastric cancer	gastric cancer	gastric cancer patients

Primary Outcome Measures

Name	Time	Method
Number of Participants With Accurate Diagnosis for Gastric Cancer	2 months	Normal subject group: number of the subjects with normal alpha 1-antitrypsin level in gastric juice Gastric cancer group: number of the subjects with elevated alpha 1-antitrypsin level in gastric juice

Trial Locations

Locations (1)

Kaohsiung Veterans General Hospital; 🇨🇳 Kaohsiung, Taiwan