Lactate Clearance and Mortality in Patients With Severe Sepsis and Septic Shock: Comparison by Hepatic Dysfunction
试验速览
- 阶段
- 不适用
- 入组人数
- 245
- 试验地点
- 1
- 主要终点
- Lactate clearance
研究概览
简要总结
The purpose of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction.
详细描述
Lactate clearance is well known to be associated with mortality in patients with severe sepsis and septic shock. To normalize lactate levels is one of important goals of early resuscitation of sepsis patients.
Lactate clearance can be changed by various factors including patient characteristics, severity of shock, and treatment. In particular, hepatic dysfunction might impair the clearance of lactate because liver is a principal organ for lactate metabolism. However, an association between lactate clearance and hepatic failure has not been evaluated during initial resuscitation of patients with severe sepsis and septic shock. The primary goal of this study is to compare lactate clearance in patients with severe sepsis and septic shock according to the presence of hepatic dysfunction. The secondary goal is to evaluate if lactate clearance is associated with mortality even in patients with hepatic dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who presented with septic shock or severe sepsis within 6 hours after emergency department arrival
排除标准
- •Terminal malignancy or illness with a expected survival < 4 months
- •Patients who previously signed "Do Not Resuscitate" or "Do Not Intubate" orders
- •Patients who do not undergo the early goal-directed therapy
结局指标
主要结局
Lactate clearance
时间窗: at 6-hour from the time of enrollment
\[(initial lactate - delayed lactate)/ initial lactate\] \*100%
次要结局
- In-hospital mortality(within the first 28-day after emergency department arrival)
研究者
Jo, Ik Joon
Associate Professor
Samsung Medical Center