Evaluate and compare the analgesic effect of morphine combined with different low dose of ketamine , as compared to morphine in trauma patients admitted to the emergency department with acute , moderate to severe pain.

Not Applicable

• Conditions: Condition 1: UPPER limb injury. Condition 2: injuries of upper limb, level unspecified. Condition 3: Other injuries of lower limb, level unspecified. Condition 4: Fracture of lower limb, level unspecified.; Fracture of upper limb, level unspecified; Other injuries of upper limb, level unspecified; Other injuries of lower limb, level unspecified; Fracture of lower limb, level unspecified

• Registration Number: IRCT2016030626927N1
• Lead Sponsor: Vice President of Research IN Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

LIMB TRAUMA;PAIN SCORE>5 ;AGE between 18-65 ; no Underlying disease ; No history of drug allergy ; No history of addiction;

Exclusion criteria:
Lack of coperation or consent of the patient during the study

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulse rate. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: counting.;Respiratory rate. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: counting.;Pain. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: vissual scale assessment.;Blood pressure. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: manometer.;O2 saturation. Timepoint: At the indicated times after injection: minutes 0 15 30 60 90 120 150 180. Method of measurement: pulse oxymetry.

Secondary Outcome Measures

Name	Time	Method
ausea. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Vomitting. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Apnea. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Hypoventiation. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Aspiration. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Confusion. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Dysphpria. Timepoint: To 3 hours after injection. Method of measurement: patient warning.;Drug reaction. Timepoint: To 3 hours after injection. Method of measurement: patient warning.