Pilot Study to investigate the role of Glutamine in the early protective stress response - Glutamine Study

St Helens & Knowsley Hospitals NHS Trust0 个研究点目标入组 30 人开始时间: 2006年5月17日最近更新: 2020年11月16日

适应症

试验速览

暂无简介。

•All admissions to intensive care less than 24 hours from admission with an illness severity APACHE II score >10.
•Aged >18 years
•Willing to consent or with consent given by relative or legal representative
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Coagulopathy, defined as 1. INR>1.5 2. Platelet count <100
•Bleeding disorder
•Hepatic impairment defined as a total billrubin concentration of more than 45 micromol/l or a more than 5 fold increase of Alanin amino transferase (ALT) above normal.
•<18 years of age
•Unwilling to consent or consent withheld by relative or legal representative
•Expected to be discharged within 48 hours from admission as judged by the Consultant in charge at the day of screening
•Expected to die within 48 hours from admission as judged by the Consultant in charge at the day of screening
•Malignant disease if not surgically resected
•Unable to perform biopsy on clinical grounds
•On total parenteral nutrition as it contains Glutamine

发起方

St Helens & Knowsley Hospitals NHS Trust