Dexmetomedine as an Adjuvant to Bupivacaine in Ultrasound Guided PECS Block

Not Applicable

Completed

• Conditions: Post Operative Pain
• Interventions: Procedure: Pecs block

• Registration Number: NCT05717114
• Lead Sponsor: Menoufia University

Brief Summary

Regional anesthesia is an essential component of anesthesia and analgesia. It has many advantages, it decreases pain post operatively, improves patient outcome and allow early recovery and ambulation Post-operative pain following breast surgery results from injured muscles and nerves, management of acute post operative pain is a consistent factor for better outcome and patient satisfaction

Detailed Description

All patients will be monitored by standard intraoperative monitoring that includes continuous electrocardiography (ECG), capnography, pulse oximetry, and non invasive blood pressure.

Induction of general anesthesia will be done by propofol 1.5-2 mg/kg and fentanyl 3µg/kg.

Tracheal intubation will be facilitated by administration of rocuronium 0.8 mg/kg. Anesthesia will be maintained with isoflurane 1MAC (Pecs block):the block will be performed with the patients in the supine position.The infraclavicular and axillary regions will be cleaned with antiseptic solution. the in plane technique will be used from proximal and medial to distal and lateral in an oblique manner at dermatome level T2 and T3.The puncture site was infiltrated with 2%lidocaine and once the structures is identified with Ultrasound

Study Timeline

• Study First Submitted: 2023-01-23
• Study First Submitted QC: 2023-01-30
• Study Start: 2023-02-05
• Study First Posted: 2023-02-08
• Primary Completion: 2023-12-25
• Status Verified: 2024-01
• Study Completion: 2024-01-01
• Last Update Submitted: 2024-01-30
• Last Update Posted: 2024-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 96

Inclusion Criteria

• adult patients
• aged 18-60years old
• ASA class 1 to 3
• scheduled for elective modified radical mastectomy

Exclusion Criteria

• patients refusal,
• coagulopathies
• concurrent anticoagulant therapy
• allergy to local anaesthetics
• infection at puncture site

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I	Pecs block	received plan bupivacaine1ml/Kg
Group II	Pecs block	received plain bupivacaine 1ml/Kg plus dexmetomedine0.5 µg/Kg
GroupIII	Pecs block	received plain bupivacaine 1ml/Kg plus dexmetomedine1µg/Kg

Primary Outcome Measures

Name	Time	Method
postoperative pain	48 hours	Visual analog score for pain where 0 no pain and 10 most severe pain

Secondary Outcome Measures

Name	Time	Method
Total morphine consumption	48 hours	Mg

Trial Locations

Locations (1)

Menoufia; 🇪🇬 Menoufia, المنوفية, Egypt