ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients
Completed
- Conditions
- Sarcoidosis
- Registration Number
- NCT04462068
- Lead Sponsor
- University of Aarhus
- Brief Summary
Sarcoidosis is a multisystem granulomatous disease of unknown cause histologically characterized by noncaseating granulomas. Genetic factors affect disease course, which is highly variable and difficult to predict.
This study aims to evaluate the predictive value of ACE and HLA genotypes on disease severity and progression in Danish patients with sarcoidosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Diagnosis of sarcoidosis
- Signed informed consent
Read More
Exclusion Criteria
- Inability or unwillingness to adhere to the study
- Inability to give informed consent
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to initiation of treatment 1 year from diagnosis Time to initiation of systemic immunosuppression for sarcoidosis
- Secondary Outcome Measures
Name Time Method Change in FEV1 1 year Increase/ decline/ no change in FEV1
Number of participants with extrapulmonary organ involvement 1 year from diagnosis Number of participants diagnosed with extrapulmonary organ involvement
Change in diffusion capacity 1 year Increase/ decline/ no change in diffusion capacity
Change in FVC 1 year Increase/ decline/ no change in FVC
Trial Locations
- Locations (1)
Aarhus University Hospital. Dep. of Respiatory Diseases and Allergology
🇩🇰Aarhus N, Denmark