Comparative Study of Personality in Parkinson's Disease Patients With Other Chronic Pain

Completed

• Conditions: Parkinson Disease
• Interventions: Other: TCI; Other: BPI; Other: CPAQ-8; Other: Social Support Questionnaire (SSQ6); Other: SF-MPQ; Other: King's Parkinson's Disease Pain Scale (KPPS); Other: PCS; Other: Hospital Anxiety and Depression scale (HAD) questionary; Other: ORT; Other: IPQ-R; Other: WCC-R

• Registration Number: NCT05713500
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

The present study compare personality of Parkinson's Disease (PD) patients with chronic, PD patients without pain and non-parkinsonian patients with other chronic pain condition.

Detailed Description

The present study would like to compare personality dimensions from the Temperament and character inventory (TCI) in four groups of patients: PD patients with chronic pain related to PD, PD patients without pain and non-PD patients with chronic pain such as fibromyalgia or chronic headache. Our aim is to evaluate if PD patients with chronic pain related to PD have a different personality than PD patients without pain and to see if this personality is specific to PD.

Study Timeline

• Study First Submitted: 2022-11-03
• Study First Submitted QC: 2023-02-03
• Study First Posted: 2023-02-06
• Study Start: 2023-02-16
• Status Verified: 2024-04
• Primary Completion: 2024-04-03
• Study Completion: 2024-04-03
• Last Update Submitted: 2024-04-05
• Last Update Posted: 2024-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• PD patients:

Patients having Parkinson's disease according to UNITED KINGDOM PARKINSON'S DISEASE SOCIETY BRAIN BANK (UKPDSBB) criteria

PD patients with chronic pain:

Patients with a pain VAS score ≥ 4 (mean VAS for the last week) Patients with a chronic pain since at least 3 months

PD patients without pain:

Patients with a pain VAS score < 3

• non PD patients:

Patients with chronic headache:

Patients with chronic headache according to the ICHD-3 beta criteria Patients with a chronic pain since at least 3 months

Patients with fibromyalgia:

Patients with fibromyalgia according to the criteria of the American College of Rheumatology 2016 (Wolfe et al., 2016) Patients with a pain VAS score ≥ 4 (mean VAS for the last week) Patients with a chronic pain since at least 3 months

• All patients:

Patient > 18 years old Patient able to give its free and informed consent Patient having a social security.

Exclusion Criteria

• PD patients:

Patients presenting atypical Parkinson's syndrome Patients having a deep brain stimulation Patients presenting a cognitive decline evaluated by a Montreal Cognitive Assessment (MoCA) score inferior to 24

• All patients:

Patient having a psychiatric disease diagnosed according to the Diagnostic and Statistical Manual-V (DSM-V) criteria such as mood disorders, psychotic disorder... None ability to give its consent Patients unable to realize the tests provided in the context of this study Patients under supervision, curatorship, or legal guardian Patients non-affiliated to a social security Patients in exclusion period of another study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-PD patients with chronic pain	ORT	Non-PD with fibromyalgia and non-PD with chronic headache
PD patients without pain	Social Support Questionnaire (SSQ6)	Parkinsonian patient without pain
non-PD patients with chronic pain	BPI	Non-PD with fibromyalgia and non-PD with chronic headache
non-PD patients with chronic pain	PCS	Non-PD with fibromyalgia and non-PD with chronic headache
PD patients with chronic pain	PCS	Parkinsonian patient with pain
PD patients with chronic pain	IPQ-R	Parkinsonian patient with pain
PD patients with chronic pain	SF-MPQ	Parkinsonian patient with pain
PD patients with chronic pain	ORT	Parkinsonian patient with pain
PD patients without pain	TCI	Parkinsonian patient without pain
PD patients without pain	ORT	Parkinsonian patient without pain
PD patients with chronic pain	BPI	Parkinsonian patient with pain
non-PD patients with chronic pain	TCI	Non-PD with fibromyalgia and non-PD with chronic headache
non-PD patients with chronic pain	CPAQ-8	Non-PD with fibromyalgia and non-PD with chronic headache
non-PD patients with chronic pain	SF-MPQ	Non-PD with fibromyalgia and non-PD with chronic headache
PD patients with chronic pain	CPAQ-8	Parkinsonian patient with pain
PD patients with chronic pain	King's Parkinson's Disease Pain Scale (KPPS)	Parkinsonian patient with pain
PD patients with chronic pain	TCI	Parkinsonian patient with pain
PD patients with chronic pain	Hospital Anxiety and Depression scale (HAD) questionary	Parkinsonian patient with pain
PD patients with chronic pain	Social Support Questionnaire (SSQ6)	Parkinsonian patient with pain
PD patients with chronic pain	WCC-R	Parkinsonian patient with pain
PD patients without pain	Hospital Anxiety and Depression scale (HAD) questionary	Parkinsonian patient without pain
non-PD patients with chronic pain	Hospital Anxiety and Depression scale (HAD) questionary	Non-PD with fibromyalgia and non-PD with chronic headache

Primary Outcome Measures

Name	Time	Method
TCI personality dimensions between the two groups of patients	24 months	compare scores of the seven TCI personality dimensions between the two groups of parkinsonian patients with or without chronic pain related to PD. This will allow to determinate if PD patients with chronic pain related to PD have a different personality than PD patients without pain

Secondary Outcome Measures

Name	Time	Method
association of personality dimensions of the TCI and in other patients with chronic pain etiology	24 months	determinate if there are some associations between TCI personality dimensions and these same previous parameters (VAS, BPI, CPAQ-8, SF-MPQ, PCS and ORT) in other patients with chronic pain etiology: 1) first, in patients with fibromyalgia, 2) then, in patients with chronic headache
exploratory objective	24 months	determinate if there are some associations between TCI personality dimensions in PD patients with chronic pain related to PD and PD-specific pain evaluated by the King's Parkinson's Disease Pain Scale (KPPS)
association between personality the seven TCI personality dimensions and different pain	24 months	determinate if there are some associations between the seven TCI personality dimensions of PD patients with chronic pain related to PD and different pain parameters: * the pain intensity evaluated with the VAS (Visual Analog Scale); * the functional discomfort evaluated with the BPI (Brief Pain Inventory); * the acceptation of pain evaluated with the CPAQ-8 (Chronic Pain Acceptance questionnaire-8); * the discriminative and affective components of pain evaluated with the SF-MPQ (short-form McGill Pain Questionnaire); * the level of catastrophism evaluated with the PCS (Pain Catastrophism Scale)
personality dimensions of the TCI and two-by-two analyses	24 months	compare personality dimensions of the TCI through two-by-two analyses between PD patients with chronic pain related to PD and patients presenting another chronic pain etiology: 1) patients with fibromyalgia, 2) patients with chronic headache. This will allow to determinate if PD patients with chronic pain have a personality specific to their PD
association between personality the seven TCI and scores	24 months	determinate if there are some associations between the seven TCI personality dimensions of PD patients with chronic pain related to PD and different pain parameters: * the pain intensity evaluated with the Visual Analog Scale (VAS); * the functional discomfort evaluated with the Brief Pain Inventory (BPI); * the acceptation of pain evaluated with the Chronic Pain Acceptance questionnaire-8 (CPAQ-8); * the discriminative and affective components of pain evaluated with the Short-Form McGill Pain Questionnaire (SF-MPQ); * the level of catastrophism evaluated with the Pain Catastrophism Scale (PCS).

Trial Locations

Locations (1)

Toulouse University Hospital (CHU de Toulouse); 🇫🇷 Toulouse, France