The Relationship Between Sarcopenia and Orthostatic Hypotension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Orthostatic Hypotension
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Change in blood pressure
- Last Updated
- 7 years ago
Overview
Brief Summary
Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries. Whether elderly sarcopenic patients have abrupt blood pressure drops upon standing remains unknown. Therefore, in this study, we sought to determine the incidence of orthostatic hypotension in sarcopenic elderly patients and compare it with elderly patients with no sarcopenia.
Investigators
Kudret Keskin
Principle Investigator
Sisli Hamidiye Etfal Training and Research Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients 75 years or older
Exclusion Criteria
- •Pace-maker
- •End stage renal insufficiency
- •End stage malignancy
- •Dehydration
- •Severe anemia ( Hgb \< 8 gr/dl)
- •Acute infection
- •Marked edema
- •Neurodegenerative disease
Outcomes
Primary Outcomes
Change in blood pressure
Time Frame: 0-3 minutes
All blood pressure measurements will be performed in the morning after an eight-hour fasting. After 5-minute rest, the first blood pressure measurement will be taken when the patients are supine. Later, three more consecutive measurements will be recorded when the patients stand up each being one-minute apart. All measurements will be performed using a fully automated sphygmomanometer that is attached with the correctly sized cuff matching to the patients' upper arm circumference. OH is defined as a decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within 3 minutes of standing. The accompanying symptoms such as dizziness, unable to maintain balance, blurred vision will also be recorded.