Sarcopenia and Orthostatic Hypotension

• Conditions: Orthostatic Hypotension; Sarcopenia
• Interventions: Diagnostic Test: blood pressure measurement

• Registration Number: NCT03732716
• Lead Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Brief Summary

Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries. Whether elderly sarcopenic patients have abrupt blood pressure drops upon standing remains unknown. Therefore, in this study, we sought to determine the incidence of orthostatic hypotension in sarcopenic elderly patients and compare it with elderly patients with no sarcopenia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-09-06
• Study Start: 2018-09-10
• Status Verified: 2018-11
• Study First Submitted QC: 2018-11-04
• Last Update Submitted: 2018-11-04
• Study First Posted: 2018-11-07
• Last Update Posted: 2018-11-07
• Primary Completion: 2018-12
• Study Completion: 2018-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients 75 years or older

Exclusion Criteria

• Pace-maker
• End stage renal insufficiency
• End stage malignancy
• Dehydration
• Severe anemia ( Hgb < 8 gr/dl)
• Acute infection
• Marked edema
• Neurodegenerative disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Elderly with sarcopenia	blood pressure measurement	50 patients aged 75 or older with sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured.
Elderly without sarcopenia	blood pressure measurement	50 patients aged 75 or older without sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured.

Primary Outcome Measures

Name	Time	Method
Change in blood pressure	0-3 minutes	All blood pressure measurements will be performed in the morning after an eight-hour fasting. After 5-minute rest, the first blood pressure measurement will be taken when the patients are supine. Later, three more consecutive measurements will be recorded when the patients stand up each being one-minute apart. All measurements will be performed using a fully automated sphygmomanometer that is attached with the correctly sized cuff matching to the patients' upper arm circumference. OH is defined as a decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within 3 minutes of standing. The accompanying symptoms such as dizziness, unable to maintain balance, blurred vision will also be recorded.

Trial Locations

Locations (1)

Şişli Hamidiye Etfal Education and Research Hospital; 🇹🇷 Istanbul, Turkey