Sequential Administration of egg development medications to the women having polycystic ovarian disease who were not responding to clomiphene citrate and treated with 3 months of oral contraceptive pill for 3 months to create hormonal balance .
Not Applicable
- Conditions
- Health Condition 1: N970- Female infertility associated withanovulation
- Registration Number
- CTRI/2022/10/046305
- Lead Sponsor
- JIPMER Intramural Research Fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Clomiphene citrate resistant polycystic ovarian syndrome women who had pretreatment with OCPs
2 BMI not more than 28
3 Normal Semen Analysis, according to 2020 WHO criteria
4 Bilateral patent tubes
Exclusion Criteria
1 Associated with Uterine or adnexal pathology as a cause for infertility .
2 History of pelvic surgery or pelvic inflammatory disease
3 Presence of Ovarian cysts
4 Thyroid or prolactin dysfunction
5 Any sensitivity to the drugs used.
6 Any history suggestive of high risk of thrombosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To Compare the efficacy Sequential Clomiphene Citrate /Letrozole with human Menopausal Gonadotropin for ovulation induction in CC resistant women with PCOS pretreated with OCPs containing Ethinyl estradiol 30ug and Drosperinone 3mg.Timepoint: outcome assessed at around day 16- day 19 in each cycle for 3 months to look for ovulation after follicular rupture i.e, in the 3rd week of each cycle
- Secondary Outcome Measures
Name Time Method To compare the pregnancy rate and live birth rate between both the gruopsTimepoint: 3 - 6 months