Investigation of Sensory Synchronized Human Brain Imaging and Neuromodulation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Major Depressive Disorder
- Sponsor
- VA Office of Research and Development
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men and women, ages 18 years and up
- •English speaking
- •Military Veterans
Exclusion Criteria
- •Those with a contraindication for MRIs (e.g. implanted metal)
- •History of head trauma with loss of consciousness
- •History of seizures or on medications that substantially reduce seizure threshold
- •Neurological or uncontrolled medical disease
- •Active substance abuse
- •Currently pregnant or breastfeeding
Outcomes
Primary Outcomes
Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change
Time Frame: 45 minutes
Change in the TMS-EEG measure will be assessed before, during, and after each TMS session. Specifically, the difference in size of the evoked response after a single TMS pulse in the frontoparietal region will be quantified in microVolts and compared between standard TMS and sensory-entrained TMS (se-TMS).