ketorolac + low dose pethidine comparison with pethidine after elective laparotomy leading to colectomy
Phase 2
- Conditions
- Pain.Other chronic painG89.29
- Registration Number
- IRCT20190325043107N20
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Weight between 45 to 115 kg
Candidate elective laparotomy leading to colectomy
Exclusion Criteria
Getting gastritis
Having unknown bleeding disorders
Pregnant women
Opioid addiction
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: The intervention will start immediately after the end of the surgery and will continue for up to two days after the surgery. The study variable will be measured every six hours from the beginning of the study for three days with the help of VAS instrument. Method of measurement: VAS.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie ketorolac and pethidine's analgesic effects in post-colectomy pain management?
How does the combination of ketorolac and low-dose pethidine compare to pethidine alone in postoperative analgesia for elective laparotomy?
Are there specific biomarkers that predict analgesic response to ketorolac-pethidine combinations in abdominal surgery patients?
What are the potential adverse events associated with ketorolac-pethidine combinations versus standard opioid analgesia after colectomy?
What alternative analgesic combinations or non-opioid approaches are being explored for post-laparotomy pain management in colorectal surgery?