Effects of Eccentric Resistance Training on Ventricle Functions and Aerobic Capacity Among Individuals With Chronic Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 84
- 试验地点
- 4
- 主要终点
- Aerobic Capacity
研究概览
简要总结
To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Care Provider, Outcomes Assessor)
盲法说明
Group allocation will be kept blinded to the assessor and to the treatment provider (trained physical therapist).
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Chronic HF and currently stable with optimal medical therapy
- •Chronic Heart failure with ejection fraction > 30 %
- •Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)
排除标准
- •Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
- •Already participating in cardiac rehabilitation
- •New York Heart Association (NYHA) Classification of HF class IV HF symptoms
- •Co-existent other disease such as asthma/ COPD/interstitial lung disease.
- •Symptomatic Second degree or third degree heart block.
- •ECG with uncontrolled ventricular arrhythmia
- •Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)
结局指标
主要结局
Aerobic Capacity
时间窗: 12 week
Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 \*Mean 6MWD (meters)
Ventricle Functions
时间窗: 12 week
Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.
次要结局
- Quality of life (Minnesota Living with Heart Failure Questionnaire)(12 week)
- Maximal strength of respiratory muscles(12 week)
- Cardiac Risk Factors - Blood Pressure(12 week)
- Cardiac Risk Factors - Body mass index(12 week)
- Strength(12 week)
- Peak Expiratory Flow (PEF)(12 week)
- Forced Expiratory Volume in 1 second (FEV1)(12 week)
- Forced vital Capacity (FVC)(12 week)
- Cardiac Risk Factors - Lipid profile(12 week)