Physiological Effects of Early Pathophysiology-driven Airway Pressure Release Ventilation (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV) in Acute Respiratory Distress Syndrome (ARDS): a Randomized Crossover Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- △PL（PLThigh - PLTlow)
研究概览
简要总结
In previous studies, airway pressure release ventilation (APRV) has been proven to be an important respiratory support method for ARDS patients, and various APRV ventilation strategies have been proposed. This study aims to compare the physiological effects of two types of APRV ventilation strategy, Early Pathophysiology-driven APRV (APRVplus) and Time-Controlled Adaptive Ventilation (TCAV), through randomized crossover trials, providing evidence for clinical application and further research on APRV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •intubated and mechanically ventilated patients
- •meet the 2023 global new definition of ARDS
排除标准
- •Pregnancy
- •The expected duration of mechanical ventilation was less than 48 hours
- •Intracranial hypertension (suspected or confirmed)
- •Neuromuscular disorders that are known to prolong the need for mechanical ventilation
- •Known or suspected chronic obstructive pulmonary disease(COPD)
- •Terminal stage of disease
- •Pneumothorax (drained or not)at enrollment
- •Treatment with extracorporeal support (ECMO) at enrollment
- •There was a lack of commitment to life support
研究组 & 干预措施
APRVplus
An Early Pathophysiology-driven Airway Pressure Release Ventilation
干预措施: APRVplus (Procedure)
TCAV
Time Controlled Adaptive Ventilation (TCAV)
干预措施: TCAV (Procedure)
结局指标
主要结局
△PL（PLThigh - PLTlow)
时间窗: during the mechanical ventilation procedure
Transpulmonary pressure swings (△PL) equal to PLThigh - PLTlow
次要结局
- EtCO2(during the mechanical ventilation procedure)
- GI(during the mechanical ventilation procedure)
- PaO2(mmHg)(during the mechanical ventilation procedure)
研究者
Zhou Yongfang
Zhou Yongfang
Sichuan University