ACTRN12618000244202已完成2 期
Relative potency of noradrenaline versus phenylephrine in the prevention of hypotension after spinal anesthesia for cesarean section
Women's Hospital, Hamad Medical Corporation;0 个研究点目标入组 60 人开始时间: 2018年2月15日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
In summary, we determined the minimal infusion rates (median effective rate, ED50) of phenylephrine and noradrenaline in prevention of hypotension after spinal anesthesia for caesarean delivery and found that noradrenaline is more potent than phenylephrine by a factor of 12.6 for equivalent maternal blood pressure control. At the minimal infusion rates, noradrenaline does not provide greater cardiac output.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 45 Years（—）
- 性别
- Female
入选标准
- •The study population will consist of patients aged 18-45 years, ASA II, BMI 25-40kg/m2, height 150–180 cm, and who have a normal singleton pregnancy beyond 36 weeks gestation, undergoing elective cesarean delivery under spinal anesthesia.
排除标准
- •onset of labor, patients with gestational hypertension, history of diabetes, cardiovascular and cerebrovascular problems, fetal abnormalities and patients taking monoamine oxidase inhibitors or tricyclic antidepressants. Moreover, all patients with baseline arterial blood pressure >140/90, or heart rate <60 or >110 beats per minute will be excluded.
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