Expression of metabolism-related genes in peripheral blood mononuclear cells in patients with dementia

Not Applicable

• Conditions: dementia; D000544

• Registration Number: JPRN-jRCT1050210166
• Lead Sponsor: Taguchi Akihiko

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-02-02
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

1)disease: Elderly healthy people and dementia patients
Dementia patients must be diagnosed with probable Alzheimer's disease according to the NIA-AA Alzheimer's disease diagnostic criteria.
In the MMSE test, dementia patients should have a score of 23 or less, and the healthy group should have a score of 28 or more.
2)others: For patients with dementia, written consent must be obtained from a substitute other than the person himself (Do not exclude the acquisition of consent from the dementia patient).

Exclusion Criteria

1)Diabetes
2)During cancer disease treatment, less than 5 years after the end of cancer treatment
3)Thyroid disease
4)Infectious diseases (AIDS, hepatitis B, hepatitis C)
5)Fever at the time of blood collection
6)Chronic subdural hematoma
7)Normal pressure hydrocephalus
8)During hemodialysis (or doctors say the need for hemodialysis soon future)
9)COPD
10)During home oxygen therapy
11)Smoking within the last 12 months
12)Taking drugs that have a clear effect on the immune system, such as anti-cancer drugs, steroids, and anti-rheumatic drugs
13)Patients with serious complications, or those who have a history of these and are judged by the investigator and the investigator to be ineligible for this study
14)Others who are judged by the principal investigator and the investigator to be ineligible for this study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expression of metabolism-related genes in peripheral blood mononuclear cells

Secondary Outcome Measures

Name	Time	Method
1) Expression of metabolism-related genes in whole peripheral blood <br>2) MMSE (cognitive Function) Examination and Frailty Interview<br>3) Complete blood count and peripheral blood image (white blood cell composition)<br>4) Blood glucose level and HbA1c (sugar, energy metabolism)