ISRCTN47673027Terminated未知
Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
orth Bristol NHS Trust0 sites80 target enrollmentStarted: April 26, 2022Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Terminated
- Sponsor
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Intubated patients with clinician suspected Gram-negative pulmonary infection requiring antibacterial therapy
- •2. Adults aged 18 years upwards
- •3. Patient admitted to ICU for at least 5 days
- •4. Patient ventilated for at least 48 hours
- •Inclusion criteria for analysis:
- •Infection with a piperacillin-tazobactam and gentamicin susceptible Gram-negative organism.
Exclusion Criteria
- •1. Patients for whom informed consent cannot be obtained
- •2. Allergies or intolerance to piperacillin-tazobactam or gentamicin
- •3. Neutropaenic sepsis
- •4. Past medical history of cystic fibrosis
- •5. Other underlying infections pulmonary process unlikely to respond to piperacillin/tazobactam with or without gentamicin (i.e. tuberculosis, fungal pneumonia)
- •6. Subject unlikely to survive longer than 24 hours
- •7. Prisoners
- •8. Pregnant women
- •9. Non-NHS patients
Investigators
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