ISRCTN47673027
Terminated
未知
Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
orth Bristol NHS Trust0 sites80 target enrollmentApril 26, 2022
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Pulmonary infection
- Sponsor
- orth Bristol NHS Trust
- Enrollment
- 80
- Status
- Terminated
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Intubated patients with clinician suspected Gram\-negative pulmonary infection requiring antibacterial therapy
- •2\. Adults aged 18 years upwards
- •3\. Patient admitted to ICU for at least 5 days
- •4\. Patient ventilated for at least 48 hours
- •Inclusion criteria for analysis:
- •Infection with a piperacillin\-tazobactam and gentamicin susceptible Gram\-negative organism.
Exclusion Criteria
- •1\. Patients for whom informed consent cannot be obtained
- •2\. Allergies or intolerance to piperacillin\-tazobactam or gentamicin
- •3\. Neutropaenic sepsis
- •4\. Past medical history of cystic fibrosis
- •5\. Other underlying infections pulmonary process unlikely to respond to piperacillin/tazobactam with or without gentamicin (i.e. tuberculosis, fungal pneumonia)
- •6\. Subject unlikely to survive longer than 24 hours
- •7\. Prisoners
- •8\. Pregnant women
- •9\. Non\-NHS patients
Outcomes
Primary Outcomes
Not specified
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