ISRCTN47673027Terminated未知
Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
orth Bristol NHS Trust0 sites80 target enrollmentStarted: April 26, 2022Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Terminated
- Sponsor
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Intubated patients with clinician suspected Gram-negative pulmonary infection requiring antibacterial therapy
- •2. Adults aged 18 years upwards
- •3. Patient admitted to ICU for at least 5 days
- •4. Patient ventilated for at least 48 hours
- •Inclusion criteria for analysis:
- •Infection with a piperacillin-tazobactam and gentamicin susceptible Gram-negative organism.
Exclusion Criteria
- •1. Patients for whom informed consent cannot be obtained
- •2. Allergies or intolerance to piperacillin-tazobactam or gentamicin
- •3. Neutropaenic sepsis
- •4. Past medical history of cystic fibrosis
- •5. Other underlying infections pulmonary process unlikely to respond to piperacillin/tazobactam with or without gentamicin (i.e. tuberculosis, fungal pneumonia)
- •6. Subject unlikely to survive longer than 24 hours
- •7. Prisoners
- •8. Pregnant women
- •9. Non-NHS patients
Investigators
Similar Trials
Completed
Not Applicable
Endotracheal Suctioning: open or closed?Mechanical ventilation, complicationsRespiratoryVentilationISRCTN75875670niversity Medical Center Utrecht (UMCU) (The Netherlands)500
Completed
Not Applicable
Safely reduce newborn antibiotic exposure with the early-onset sepsis calculator: a cluster randomized studyearly-onset neonatal sepsis10004018neonatal sepsisNL-OMON52299Tergooiziekenhuizen1,830
Not yet recruiting
Phase 3
Antibiotic Prophylaxis for preventing infectious complications in Orthognathic SurgeryK07.1K07.2Anomalies of jaw-cranial base relationshipAnomalies of dental arch relationshipDRKS00022838Ruprecht-Karls-University Heidelberg, Medical Faculty represented by Universitätsklinikum Heidelberg1,420
Completed
Not Applicable
Early discontinuation of antibiotic prophylaxis in patients with persistent p rimary vesicoureteral reflux initially detected during infancy: outcome analys is and risk factors for febrile urinary tract infectioprimary vesicoureteral refluxJPRN-UMIN000017459Hokkaido University Hospital70
Completed
Not Applicable
Reduction of antibiotic resistance in uncomplicated urinary tract infections by treatment according to national guidelines in the ambulatory careN30.0N30.9N39.0Cystitis, unspecifiedUrinary tract infection, site not specifiedAcute cystitisDRKS00020389niversitätsklinikum Würzburg Geschäftsbereich 1 – Forschungsförderung und Drittmittelmanagement128