ISRCTN47673027终止未知
Minimising the risks of emergence of antibiotic resistance during therapy by precise regimen individualisation and use of combination therapy
orth Bristol NHS Trust0 个研究点目标入组 80 人开始时间: 2022年4月26日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 终止
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Intubated patients with clinician suspected Gram-negative pulmonary infection requiring antibacterial therapy
- •2. Adults aged 18 years upwards
- •3. Patient admitted to ICU for at least 5 days
- •4. Patient ventilated for at least 48 hours
- •Inclusion criteria for analysis:
- •Infection with a piperacillin-tazobactam and gentamicin susceptible Gram-negative organism.
排除标准
- •1. Patients for whom informed consent cannot be obtained
- •2. Allergies or intolerance to piperacillin-tazobactam or gentamicin
- •3. Neutropaenic sepsis
- •4. Past medical history of cystic fibrosis
- •5. Other underlying infections pulmonary process unlikely to respond to piperacillin/tazobactam with or without gentamicin (i.e. tuberculosis, fungal pneumonia)
- •6. Subject unlikely to survive longer than 24 hours
- •7. Prisoners
- •8. Pregnant women
- •9. Non-NHS patients
研究者
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