NCT01939795已完成不适用
Effect of Physical Training Combined Cardiac Resynchronization Therapy in Heart Failure Patients
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Sympathetic nerve activity
研究概览
简要总结
The investigators hypothesis that exercise training would potentiate the effects of cardiac resynchronization therapy in heart failure patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •QRS> 150 ms or 120-150ms associated dyssynchrony
- •The etiology can be idiopathic, ischemic, hypertensive and Chagas' disease
- •Ejection fraction <35%
- •The optimal pharmacological treatment for heart failure
排除标准
- •Exclusion Criteria:
- •Patients with pulmonary diseases, neurological diseases, renal, skeletal muscle diseases
- •Patients with contraindications to implant a cardiac pacemaker
- •Pregnancy
- •New York Heart Association functional class IV
- •Atrial fibrillation
研究组 & 干预措施
Healthy People
No Intervention
Control group
Untrained CRT
Experimental
Untrained CRT patients
干预措施: exercise training and/or CRT (Other)
Exercise trained + CRT
Experimental
Exercise-trained CRT patients
干预措施: exercise training and/or CRT (Other)
结局指标
主要结局
Sympathetic nerve activity
时间窗: 4 months
Sympathetic nerve activity will be assessed by microneurography
次要结局
- Peak oxygen consumption(4 months)
- Muscle Blood Flow(4 months)
- skeletal muscle strength(4 months)
- Quality of life(4 months)
- Blood inflammatory markers(4 months)
研究者
Thaís Simões Nobre Pires Santos
Phd student
University of Sao Paulo General Hospital
研究点 (1)
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