Assessment of Pulmonary Function in Relation to the Anesthetic Used in Patients Undergoing Bariatric Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Different drug type for conduction of general anesthesia
- Conditions
- Obesity and Obesity-related Medical Conditions
- Sponsor
- Medical University of Gdansk
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Pulse oximetry (SpO2)
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
It is known that more or less pronounced impairment of pulmonary function occurs after anesthesia. It has been demonstrated in the postoperative period in both patients undergoing general and regional anesthesia, in patients after intra-abdominal and superficial procedures, in overweight and normal-weight patients. It has also been shown that when general anesthesia is performed with the inhalation anesthetic sevoflurane, there is a slightly smaller reduction in lung function parameters than when only intravenous anesthetics are used.
The purpose of this study is to evaluate lung function before induction and after awakening from general anesthesia depending on the inhalational anesthetic used in obese patients undergoing bariatric surgery
Investigators
Radosław Owczuk
Prof. dr hab.
Medical University of Gdansk
Eligibility Criteria
Inclusion Criteria
- •Obese patients qualified for bariatric surgery.
Exclusion Criteria
- •Patients who have absolute contraindications to spirometry testing, i.e:
- •with aneurysms of the aorta or cerebral arteries threatening to rupture, after recent vascular surgery
- •with increased intracranial pressure, after recent intracranial bleeding or head surgery within the cranial cavity
- •after acute conditions within 6 months prior to surgery such as stroke, myocardial infarction, unstable angina, pneumothorax
- •with uncontrolled hypertension
- •after recent eye surgery or a history of retinal detachment
- •with hemoptysis of unknown etiology. And patients unable to perform spirometry testing
Arms & Interventions
General anesthesia with desflurane
Patients undergoing anesthesia for bariatric surgery with desflurane as a volatile agent.
Intervention: Different drug type for conduction of general anesthesia
General anesthesia with sevoflurane
Patients undergoing anesthesia for bariatric surgery with sevoflurane as a volatile agent.
Intervention: Different drug type for conduction of general anesthesia
Outcomes
Primary Outcomes
Pulse oximetry (SpO2)
Time Frame: Continuously during whole duration of anesthesia
SpO2 will be measured by light spectrometry percutaneous sensor in %
Heart rate (HR)
Time Frame: Continuously during whole duration of anesthesia
HR will be measured by ecg in beat per minute
End tidal CO2 (etCO2)
Time Frame: Continuously during whole duration of anesthesia
etCO2 will be measured by capnography with infrared radiation sensor in mmHg. Sensor will be attached to breathing circuit.
Area of reactance (Ax)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
Ax will be measured with impulsed oscillometry
Minimum alveolar concentration (MAC)
Time Frame: Continuously during whole duration of anesthesia
MAC will be measured based on exhaled anesthetic gas concentration in absolute numbers
Bispectral index (BIS)
Time Frame: Continuously during whole duration of anesthesia
BIS will be measured with Covidien BIS monitoring system in absolute numbers
Forced vital capacity (FVC)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
FVC will be measured with spirometry
Volume that has been exhaled at the end of the first second of forced expiration (FEV1)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
FEV1 will be measured with spirometry
Train of for (TOF)
Time Frame: Every 2.5 minutes during whole duration of anesthesia
TOF will be measured in absolute numbers
Non invasive blood pressure (NIBP)
Time Frame: Every 5 minutes during whole duration of anesthesia
NIBP will be measured with oscillometric method in mmHG
Mid-expiratory flow; the rates at 25% FVC (MEF25)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
MEF25 will be measured with spirometry
Mid-expiratory flow; the rates at 25% FVC (MEF50)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
MEF50 will be measured with spirometry
Peak expiratory flow (PEF)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
PEF will be measured with spirometry
Respiratory input impedance (Zrs)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
Zrs will be measured with impulsed oscillometry
Resistive component (Rrs)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
Rrs will be measured with impulsed oscillometry
Reactive component (Xrs)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
Xrs will be measured with impulsed oscillometry
Resonant frequency (Fres)
Time Frame: 3 months before the surgery and 10 and 30 minutes after the emergence from general anesthesia
Fres will be measured with impulsed oscillometry