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Clinical Trials/NCT06189807
NCT06189807
Active, not recruiting
Not Applicable

Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD): A Pilot Study

University of Michigan1 site in 1 country70 target enrollmentFebruary 14, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
CKD
Sponsor
University of Michigan
Enrollment
70
Locations
1
Primary Endpoint
Preparation for Decision Making (PrepDM) score at post-intervention
Status
Active, not recruiting
Last Updated
5 months ago

Overview

Brief Summary

This pilot study will assess the efficacy of a pregnancy and contraception education decision aid (DA) for patients with chronic kidney disease to support decisions about reproductive health, and will assess feasibility and acceptability of the intervention to inform future Research Project Grant (R01) level studies.

Detailed Description

60 patient participants will receive either a novel DA about pregnancy and contraception in chronic kidney disease delivered by patient's nephrologist or will receive currently available educational materials based on clinic-level randomization. Nephrologists will be trained to deliver the novel decision aid or will provide usual care. Patients will complete a survey about pregnancy and contraception decision making and the acceptability and feasibility of the educational materials after the clinical visit. Intervention nephrologists will be anonymously surveyed after all patients have completed measures, to assess acceptability and feasibility.

Registry
clinicaltrials.gov
Start Date
February 14, 2024
End Date
September 25, 2026
Last Updated
5 months ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Andrea Oliverio

Assistant Professor

University of Michigan

Eligibility Criteria

Inclusion Criteria

  • Any Chronic Kidney Disease (CKD) diagnosis
  • CKD defined as abnormality in kidney structure or function for \>3 months and may be manifested by having any one of the following:
  • i. Glomerular filtration rate (GFR)\<60 milliliter/Minute (ml/min)/1.73m2, or
  • ii. A marker of kidney damage (albuminuria \>30 milligrams per gram (mg/g), abnormal kidney histology by biopsy, hematuria, structural abnormalities by imaging (e.g. polycystic kidney disease, horseshoe kidney) or electrolyte abnormalities due to tubular disorders)
  • \- Able to speak and read English

Exclusion Criteria

  • Patients receiving dialysis
  • Patients who have a kidney transplant
  • Patients that are surgically sterile (tubal ligation or hysterectomy) or currently pregnant
  • Patients that have significant cognitive or visual impairment that limits interaction with the decision aid (DA)

Outcomes

Primary Outcomes

Preparation for Decision Making (PrepDM) score at post-intervention

Time Frame: Day 1- 7 (post appointment with provider)

This is a 10-item survey that participants answer not at all (1) to a great deal (5). PrepDM is scored on a 0-100 scale, where higher score indicates better preparation for decision making. A score of \>75 is a clinically significant cut off that indicates participants being well prepared to make decisions after reviewing a DA.The PrepDM scale was adapted slightly to meet the needs of the target population and the developed novel decision aid.

Secondary Outcomes

  • Feasibility of delivering a reproductive health decision aid in an academic nephrology clinic measured by the percentage of enrolled patients in the intervention clinics that providers reviewed contraception or pregnancy planning with participants during(Day 1 (Visit at the clinic))
  • Acceptability of delivering a reproductive health decision aid in a nephrology clinic -participants(Day 1- 7 (post appointment with provider))
  • Feasibility of delivering a reproductive health decision aid in a nephrology clinic - nephrologists(12 months)
  • Feasibility of delivering a reproductive health decision aid in an academic nephrology clinic measured by proportion of approached patients that consent during screening period(12 months (after recruitment starts))
  • Acceptability of delivering a reproductive health decision aid in a nephrology clinic- nephrologists(12 months)

Study Sites (1)

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