Het effect van fenretinide op insulinegevoeligheid.
Recruiting
- Conditions
- ObesityMetabolic syndrome XInsulin resistanceFatty liver
- Registration Number
- NL-OMON25232
- Lead Sponsor
- Academic Medical Center (AMC)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Post menopausal female;
2. Age 40-65 years;
Exclusion Criteria
1. T2DM treated with medication other than metformin or sulfonylurea derivates;
2. Any medical condition except for glucose intolerance, T2DM, hypertension and secondary dyslipidemia;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in hepatic and peripheral insulin sensitivity.
- Secondary Outcome Measures
Name Time Method 1. Liver steatosis;<br /><br>2. Plasma retinol and RBP4 levels;<br /><br>3. Subcutaneous adipose tissue: Concentrations of RBP4 and key proteins involved in insulin signaling levels;<br /><br>4. Plasma HPR and its metabolites (MPR, 4-oxo-HPR) levels;<br /><br>5. Resting energy expenditure (REE) and body fat composition;<br /><br>6. Glucoregulatory hormones, adipokines and markers of inflammation;<br /><br>7. Safety and tolerability of HPR/LXS.