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Clinical Trials/NCT04832867
NCT04832867
Unknown
Not Applicable

Pulmonary Rehabilitation in COVID-19 Patients: The Initial Results of Acute and Subacute Rehabilitation

Bakirkoy Dr. Sadi Konuk Research and Training Hospital1 site in 1 country300 target enrollmentJanuary 1, 2021
ConditionsCovid19

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Covid19
Sponsor
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Enrollment
300
Locations
1
Primary Endpoint
mMRC dyspnea scale
Last Updated
5 years ago

Overview

Brief Summary

It was aimed to evaluate the respiratory functions of patients who were given respiratory rehabilitation, bed positioning and early mobilization, and the time of leaving the hospital.

Detailed Description

According to the clinical classification of the World Health Organization, COVID-19; It manifests itself in a wide spectrum, ranging from mild illness, Pneumonia, Severe pneumonia, Acute respiratory distress syndrome (ARDS), to Sepsis and septic shock, resulting in death. In the presence of acute respiratory failure, a decrease in lung compliance leads to increased respiratory work, impaired blood oxygenation, and rapid and superficial breathing patterns. In this case, minimizing inspiratory effort and maximizing the mechanical efficiency of breathing is the most important approach of treatment. In these clinical conditions, the strength of the respiratory muscles may also be reduced. The challenge of COVID-19 requires a multidisciplinary approach. Rehabilitative intervention should be a part of the treatment pathway from the early stages of the disease. There is an urgent need to build information based on the most effective non-pharmacological measures to ensure the earliest discharge and best recovery after complex COVID-19 infection. Multimodal rehabilitation at all stages of the disease should be part of a holistic medical approach, but there is still no consensus on the timing and type of intervention. According to the clinical classification of COVID-19 disease, especially according to the WHO clinical classification, 2.-4. The respiratory system is significantly affected during the stages. In addition, after the active phase of the disease, it is not clear how much damage or sequelae will remain in patients, as there is not enough information about the long-term consequences. In the appropriate patient, pulmonary rehabilitation interventions at the appropriate time will definitely be required. The aims of pulmonary rehabilitation in general are: • To keep the respiratory tract open; To reduce respiratory tract resistance and improve ventilation by preventing secretion accumulation with positioning, mobilization, effective cough and other secretion drainage methods, The diaphragm and other respiratory muscles in a more normal position and function. to ensure that With a breathing pattern that improves the respiratory task and reduces air entrapment reducing the respiratory rate, * To reduce respiratory work / burden and energy consumption during breathing with appropriate training, * To prevent or increase chest mobility with exercises suitable for the individual, to detect postural deformities in the musculoskeletal system due to lung disorders, to prevent and / or correct deformity development with appropriate exercise prescription, * To reduce dyspnea and to relax, * To improve endurance and general exercise tolerance, * Suppressing anxiety, depression and anxiety, * To improve the loss of function and quality of life. Pulmonary rehabilitation consists of the following items in scope: Exercise training; respiratory and physical exercise training and breathing strategies * Work and occupation therapy * Patient education and smoking cessation * Nutritional assessment and support * Psychosocial support * Long-term oxygen therapy * Use of non-invasive and invasive mechanical ventilation Exercise training in pulmonary rehabilitation; It is the most important and obligatory one among the PR elements, it can be thought that it will be the most effective in meeting the PR objectives.

Registry
clinicaltrials.gov
Start Date
January 1, 2021
End Date
May 1, 2021
Last Updated
5 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Responsible Party
Principal Investigator
Principal Investigator

Meltem Vural

principal investigator

Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Eligibility Criteria

Inclusion Criteria

  • Being over 18 years old
  • Those who have been hospitalized since 11.01.2020
  • Those who have been consulted to the physical therapy clinic since 11.01.2020

Exclusion Criteria

  • Fever ˃38.0 °
  • Initial consultation time ˂7 days
  • In those with 3 days from the onset of the disease to shortness of breath Chest radiographic scans showing 50% progression within 24 to 48 hours
  • With Spo2 level ≤95%
  • Resting blood pressure ˂90 / 60 (1mmHg = 0.133kPa) or ˃140 / 90mmHg. 100 heart rate per minute Those with moderate and / or severe heart disease

Outcomes

Primary Outcomes

mMRC dyspnea scale

Time Frame: change from baseline at 1 month

THe mMRC dsypnea scale quantifies disability attributable to breathlessness and is useful for charecterizing baseline dyspnea in patients with respiratory disease. describes baseline dyspnea but does not accurately quantify response to treatment of chornic obstructive pulmonary disease (COPD).

GLASKOW COMA SCALE

Time Frame: change from baseline glaskow coma scale at 1 months

The scale was described in 1974 by Graham tesdale and Bryan Jenett as a way to communicate of patients with an acute brain injury. A person's GCS score can range from 3 (completely unresponsive) to 15 (responsive). This score is used to guide immediate medical care after a brain injury (such as a car accident) and also to monitor hospitalized patients and track their level of consciousness. The glasgow coma scale is often used to help define the severity of TBI. Mild head injuries are generally defined as those associated with a glasgow coma scale score of 13-15, and moderate head injuries are those associated with a glasgow coma scale score of 9-12. A glasgow coma scale score of 8 or less defines a severe head injury.

Secondary Outcomes

  • SpO2(change from baseline at 1 month)
  • carbon dioxide (CO2)(change from baseline at 1 month)
  • cardiac output test(change from baseline at 1 month)

Study Sites (1)

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