The Use of Antipsychotics in the Program of All-inclusive Care for the Elderly (PACE)

Completed

• Conditions: Behavioral and Psychiatric Symptoms of Dementia

• Registration Number: NCT03692182
• Lead Sponsor: Tabula Rasa HealthCare

Brief Summary

The aim of this study is to retrospectively evaluate and describe the use of antipsychotics among participants enrolled in the Program of All-inclusive Care for the Elderly (PACE), a community-based practice setting.

Detailed Description

Much national attention has been given to assessing and reducing the use of antipsychotics among nursing home residents, yet comparatively little attention has focused on antipsychotic use among older adults receiving care in community-based settings. The primary objective of this study is to determine the prevalence of antipsychotic use among a nationally representative sample of nursing home-eligible older adults in a community-based practice setting known as Program of All-inclusive Care for the Elderly (PACE). The secondary objectives are focused on characterizing antipsychotic use within PACE and for these participants. Specifically, the investigator's secondary objectives are to describe patterns of other drugs concomitantly used with antipsychotics (e.g., benzodiazepines, opioids) and to identify clinically relevant drug-drug interactions involving antipsychotics.

Study Timeline

• Study Start: 2017-01
• Primary Completion: 2017-12
• Study First Submitted: 2018-09-25
• Study First Submitted QC: 2018-09-28
• Study First Posted: 2018-10-02
• Study Completion: 2019-03
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-09
• Last Update Posted: 2019-09-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10000

Inclusion Criteria

• Participant enrolled in PACE contractually receiving pharmacy services from Tabula Rasa Healthcare CareKinesis Pharmacy (Tabula Rasa HealthCare) during the project time period (January 2017 through December 2017).

Exclusion Criteria

• Participant with a diagnosis of bipolar disorder and/or schizophrenia, according to pharmacy records.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of Antipsychotic Use	12 months	Quantitative description of antipsychotic use as assessed by pharmacy records

Secondary Outcome Measures

Name	Time	Method
Drug-Drug Interactions	12 months	Qualitative and quantitative description of drug-drug interactions involving antipsychotics as assessed by proprietary clinical decision support system (CDSS)
Concomitant Drug Use with Antipsychotics	12 months	Qualitative and quantitative description of patterns of other drugs concomitantly used with antipsychotics as assessed by pharmacy records

Trial Locations

Locations (1)

Tabula Rasa HealthCare; 🇺🇸 Moorestown, New Jersey, United States