NCT02767622已完成不适用
Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 主要终点
- Improvement of Psychometric tests.
研究概览
简要总结
This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls before and 6 months after liver transplantation. Assessment of cognitive functions by Trail Making Test A (TMT A), TMT B, Digit Symbol Test (DST), and Serial Dotting Test (SDT) was done before and after liver transplantation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation
排除标准
- •Overt hepatic encephalopathy.
- •Significant cortical atrophy or other structural brain changes revealed by conventional neuro-imaging.
- •Regular use of psychotropic drugs, such as benzodiazepines.
- •Known major psychiatric disorder.
- •Less than 6 months of complete alcohol abstinence.
- •Post-transplant toxic levels of immunosuppressive drugs.
- •Patients unable to perform the tests (Illiterate or upper limb motor handicaps).
结局指标
主要结局
Improvement of Psychometric tests.
时间窗: 6 months following liver transplantation.
次要结局
- Improvement of liver functions and MELD score following liver transplantation.(6 months following liver transplantation.)
研究者
Sara Abdelhakam
Assistant Professor
Ain Shams University
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