EFFEFT OF AUSHADHI PANCHAMRITA IN OJAKSHAYA

Phase 2

Not yet recruiting

Conditions: Disorder involving the immune mechanism, unspecified. Ayurveda Condition: OJAKSHAYAH,

Registration Number: CTRI/2021/02/031087

Lead Sponsor: DrSarvepalli Radhakrishnan Rajasthan Ayurved University Jodhpur

Brief Summary: Ayurveda the age-old science of life has contributed as a major system in maintain and fulfilling the health-related needs of human society. This science has witnessed drastic changes in environments, lifestyle and so on. This had been possible because of strong, universal, unchanged principles of Ayurveda*.* The epitome of Ayurveda science and utility is firmly standing on fundamental principles of Ayurveda *Ojas* literally means â€œvigorâ€. The *Ojas* is one of the tools for the achievement of this aim. *Acharaya Sushruta* describes *Oja*s as the *Paramateja* of the *Saptadhatus* and as the *Bala* or biological strength of an individual. *Ojas* act as resistance to *Roga* which prevents abnormalities in body and acts as protection against various antigens & foreign bodies. It is the quite essential for our life, energy and exists on a subtle level in the body. Disease strikes at the location where there is derangement of *Ojas*. The diseases such as AIDS, Diabetes, *Pandu*, *Rajaykshma*, *Ghrahani* etc, can manifest features of decreasing immunity or rather *Ojakshaya*. *Vyaadhiksamatva*, literally means "resistance (*Ksamatva*) against disease (*Vyadhi*).

Ayurveda also mentioned a number of methods to encourage *Ojas* & *Vyadhikshamtva*. Factors which contribute for *Vyadhikashamatva* are normal *Dosa*, equilibrium state of *Dhatu*, normal *Agni*, and patency of *Srotasa* etc. Protection of health and maintenance of *Arogyata* is the main aim of Ayurveda. The Physical and mental resistance to disease is of enormous significance to all living beings; it regulates both, prevention against and rapid recovery from diseases. *Ojas* is located in *Haridya* (heart) & infiltrates all over the body.

*Acharya Charaka* describe *Oja*s *Kshaya* symptoms like as *Vibheti* (Person suffer from fear complex), *Durbalo Abhikshanam* (Physical and mental debility), *Vyathita indriya* (Feel discomfort in the sense organ), *Duschhaya* (Developed impaired), *Durmana* (Bad mentationâ€™s), *Ruksha* (Dryness), *Ksama* (Emaciation of the body). *Acharyas* are describes drugs in various Ayurvedic text for *Ojaskshaya* like *Aushadhi Panchamrit*a *yog*.

**AIMS AND OBJECTIVES: -**

1. To Study the Physiology of *Ojas* along with its function and the references available in classical ayurvedic texts

2. Detail study about *ojakshaya* as mentioned in ayurvedic texts.

3. To evaluate the efficacy of *Aushadhi Panchamrita Yog* in *ojakshaya*.

SIGNIFICANCE OF STUDY: -Due to *Ativyayama, Anashana, Chinta, Pramitashana, Vata-atapsevana, Bhaya, Shoka, Rukshapaan, Prajagarn, Kala, Abhighata, Ativyavaya* etc. there are increased incidence of *Ojakshaya* in practice and other systems fail to find a satisfactory solution for it. Therefore, it is necessary to find a solution for it through Ayurveda. An attempt is made to clinically evaluate the efficacy of *Aushadhi Panchamrita Yog* in the treatment of *Ojakshaya*.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

1.Patients full filling the classic signs and symptoms of Ojakshaya will be selected.
2.16-60 age group patients will be taken.
3.Patients of either gender will be taken to study.

Exclusion Criteria

1. Individuals below 16 years and over 60 years of age. 2. Patients with any chronic systemic disorders, such as â€“Madhumeha, Rajaksma, Atisara, Pandu etc. 3. Patient taking any other medication in the duration of study. 4. Pregnant lady and lactating mothers. CRITERIA FOR WITHDRAWAL:.
1. During the course of trial, if any serious conditions or any serious adverse events which requires urgent treatment. 2. Patients himself wants to withdraw from the clinical trial.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IMPROVEMENT IN SUBJECTIVE PARAMETER I.E. SIGNS and SYMPTOMPS OF OJAKSHAYA	2 MONTHS(60 DAYS)
1.VIBHETI 2.DURBALOABHIKSHANAM 3.ABHIKSNAM DHYAYATI 4.VYATHITA INDRIYA 5.DUSCHHAYA 6.DURMANA 7.RUKSHA 8.KSAMA 9.MURCHHA 10.MANSAKSHYA 11.MOHA 12.AGYANA	2 MONTHS(60 DAYS)
13.PRALAPA	2 MONTHS(60 DAYS)
14.MRITYU	2 MONTHS(60 DAYS)

Secondary Outcome Measures

Name	Time	Method
IMPROVEMENT IN OBJECTIVE PARAMETER	1.Complete blood count (CBC)

Trial Locations

Locations (1): P.G. Department of Kriya Sharira, University College of Ayurveda,
🇮🇳
Jodhpur, RAJASTHAN, India
P.G. Department of Kriya Sharira, University College of Ayurveda,
🇮🇳Jodhpur, RAJASTHAN, India
DR SANGEETA SINGH MD SHOLAR
Principal investigator
6375900945
drsangeetasingh1992@gmail.com