A Randomized, Cross-Over Trial to Evaluate the Acute Effects of Black Pepper on Energy Expenditure and Fat Oxidation in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Energy expenditure and substrate oxidation
研究概览
简要总结
As obesity rates worldwide continue to increase, there is a focus on identifying active food ingredients which increase metabolic rate which can be used as a dietary supplement in the treatment of overweight and obesity. Promising animal and cell studies have suggested a role for black pepper and an active component of black pepper, piperine, in energy expenditure. However, the effects of black pepper have not been determined in humans. The investigators hypothesis if that consumption of 1.5g black pepper (0.5g in each of three meals over one day) will result in an elevation in 24-h resting energy expenditure when contrasted to a control day (no black pepper, same diet intake).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal
- •Aged 50-65 years
- •BMI 25-35kg/m2
- •Not taking blood pressure or anti-inflammatory medications or any other medications that may impact the results
- •Thyroid hormone profile within the normal reference range
- •No medical condition which may impact the results (e.g. diabetes)
- •Accustomed to eating regular meals including breakfast
排除标准
- •Heavy exerciser (defined as >150 minutes/week for more than 3 months)
- •Abuses alcohol or drugs
- •Vegetarian
结局指标
主要结局
Energy expenditure and substrate oxidation
时间窗: 24-hours
A primary outcome of this study was the 24-hour energy expenditure (measured in the metabolic chamber at the UNC NRI) following black pepper and no pepper control.
次要结局
- Gut peptides(30 minutes after lunch)