A Phase 3 Randomized Trial of Concurrent Cisplatin And Radiotherapy With or Without OncoVEXGM-CSF in Previously Untreated Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck

• Conditions: ocally Advanced Squamous Cell Carcinoma of the Head and Neck; MedDRA version: 12.1Level: LLTClassification code 10041823Term: Squamous cell carcinoma

• Registration Number: EUCTR2010-019071-29-GB
• Lead Sponsor: BioVex, Inc.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03-29
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 580

Inclusion Criteria

1. Male or female = 18 years.
2. ECOG Performance Status = 1.
3. Histological evidence (from the primary lesion and/or lymph nodes) of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx.
4. Stage III or IV disease (T2N2-3M0, T3-4 N1-3 M0).
5. No evidence of distant metastases by CT or PET/CT scan.
6. Life expectancy = 4 months.
7. Neutrophil count = 2,000/mm^3.
8. Platelet count = 100,000/mm^3.
9. Hemoglobin = 10 g/dL.
10. Bilirubin = 1.5 times ULN s.
11. AST and ALT = 2.5 times ULN.
12. Alkaline phosphatase = 2.5 times ULN.
13. Creatinine clearance = 60 mL/min.
14. Female patients of child-bearing potential (i.e. not surgically sterile, or not having
spontaneous amenorrhea for at least 12 months) must agree to use an effective form of contraception during the treatment phase of the study.
15. Male patients must agree to use a condom with spermicide or their female partner must use an effective method of birth control.
16. Provide written informed consent in accordance with all applicable regulations and follow the study procedures. Patients must be capable of understanding the
investigational nature, potential risks and benefits of the study.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

1. Prior treatment for locally advanced SCCHN (NO prior surgery for SCCHN except
nodal sampling or biopsy for study disease).
2. Patients with T1-2N1 or T1N2-3.
3. Pre-existing peripheral neuropathy = Grade 2 (motor or sensory).
4. Weight loss > 20% of body weight within 3 months of screening (unless purposeful).
5. Surgery = 28 days before randomization with the exception of feeding tube
placement, dental extractions, central venous catheter placement, biopsies and
nodal sampling.
6. Cancer of the nasopharynx, sinus, salivary gland or skin.
7. Previous radical RT to the head and neck region, excluding superficial RT for a nonmelanomatous skin cancer.
8. Prior cancers, except: those diagnosed > 5 years ago with no evidence of disease
recurrence and clinical expectation of recurrence of less than 5%; or successfully treated non-melanoma skin cancer; or carcinoma in situ of the cervix.
9. Significant intercurrent illness that will interfere with the chemotherapy or radiation
therapy such as HIV infection, cardiac failure, pulmonary compromise (chronic
obstructive pulmonary disease, pneumonia or respiratory decompensation) resulting
in hospitalization within 12 months of screening, or active infection.
10. Any significant cardiac disease (e.g., New York Heart Association (NYHA) Class 3 or 4; myocardial infarction within the past 6 months; unstable angina; coronary
angioplasty or coronary artery bypass graft (CABG) within the past 6 months; or
uncontrolled atrial or ventricular cardiac arrhythmias).
11. High risk for poor compliance with therapy or follow up as assessed by the
investigator.
12. Active herpes labialis, other lesions due to HSV1 or dermatoses involving or within 50 cm of the lesions to be injected; active HSV1 lesions must have resolved before OncoVEXGM-CSF is injected.
13. Prior systemic chemotherapy for any type of cancer.
14. Patients for whom radiation therapy is contraindicated.
15. Pregnant or breast-feeding female. Confirmation that women of child-bearing
potential are not pregnant. A negative serum ß- human chorionic gonadotropin (ß-
hCG) pregnancy test result must be obtained during the screening period.
16. Currently enrolled and receiving an investigational agent in a clinical research study or received an investigational agent for any reason within 4 weeks prior to screening.
17. Require intermittent or chronic treatment with an anti-herpetic drug (e.g., acyclovir), other than intermittent topical use.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified