Invloed van inspanning door middel van wielrennen op het haemostatisch profiel.
Recruiting
- Conditions
- Exercise, coagulation, platelet reactivity, thrombin generation, endofibrosis, cycling
- Registration Number
- NL-OMON20436
- Lead Sponsor
- Maastricht University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Minimal 18 years old;
2. Trains more than 3 times a week;
Exclusion Criteria
1. Diagnosed with coagulation or platelet disorder;
2. Using medication against coagulation or platelet function;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expecting to show increased coagulation activity by increased TAT levels, supported by decreased Coagulation Time (CT) and enhanced Maximal clotting formation (MCF) by Rotem and enhanced thrombin generation through CAT assay. Increased fibrinolytic activity is expected by increased tPA and D-Dimer levels. Coagulation activation via the intrinsic pathway can be showed by enhanced thrombin generation in Active Side Inhibitor factor Seven (ASIS) assay. Increased platelet reactivity is expected by multiplate accompanied by a increase in platelet count. Moreover we expect increase vWf levels, due to endothelial dysfunction.
- Secondary Outcome Measures
Name Time Method Secondary outcomes can be a change in Hematocrit and Haemoglobin, due to plasma volume changes.<br><br /><br /><br>Moreover, outcomes can be that cycling exercise induces a internal haemostatic profile that can contribute to pathofysiological disease which are very common in cycling, endofibrose of the iliacal artery. Characterized by subendothelial fibrotic tissue formation. Protease Activated Receptors are known that they can induce fibrotic tissue formation and can be activated by coagulation factors (FXa and Thrombin).