Which is better in between Nebulized Polymyxin E and Nebulized Amikacin for the prevention ofventilator-associated pneumonia
Phase 4
- Conditions
- Health Condition 1: J958- Other intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified
- Registration Number
- CTRI/2024/07/070824
- Lead Sponsor
- ttarpradesh University of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients who are expected to be on mechanical ventilation for at least 72 hours.
Exclusion Criteria
1. Patients who are already on mechanical ventilation for more than 96 hours.
2.Patients who are already diagnosed with or a suspected case of pneumonia
3.Patient with chronic kidney disease
4. Positive pregnancy test at the time of inclusion
5. Patient scheduled for extubation within the next 24 hours
6. Patient known to be allergic to aminoglycosides or polypeptide antibiotics at the time
of inclusion.
7. Patients who are already on systemic aminoglycoside or polypeptides antibiotics
8.Patients who are tracheostomized.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the first episode of VAP in between the two groups from randomization <br/ ><br>to Day 28 on the basis of Clinical Pulmonary Infection Score(CPIS),Timepoint: 28 Days
- Secondary Outcome Measures
Name Time Method To compare the median number of days from randomization to first successful <br/ ><br>spontaneous breathing trial.Timepoint: 28 Days;Adverse reaction in between the two groups due to nebulization.Timepoint: 28 Days;To compare the median length of stay in days (ICU and Hospital).Timepoint: 28 Days;To compare the median number of days on mechanical ventilation from <br/ ><br>randomization to Day 28.Timepoint: 28 Days