The effect of bile acid binding with colesevelam on postprandial glucose concentrations in patients after RYGB and cholecystectomy : a meal test study

Medical Center Leeuwarden0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

试验速览

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•RYGB patients, 2 years or more after surgery with a history of cholecystectomy, 20 to 60 years of age, with a stable weight (+/- 5 Kg in last 3 months) and without complaints of PBH

•-(history of ) diabetes
•-hypertriglyceridemia
•-Known gastro-intestinal disease or history of gastro-intestinal disease, e.g. celiac disease, inflammatory bowel disease
•-Known addiction behaviour
•-Suspected compliance problems
•-Intolerance to colesevelam
•-Renal or hepatic insufficiency
•-Medication influencing glucose metabolism
•-Medication influencing bile-acid metabolism, e.g. ursodeoxycholic acid
•-Critical medication of which absorption can be compromised by colesevelam and can not be ingested at least 4 hours before or later than colesevelam(e.g. levothyroxine, verapamil, fenytoïne, glibenclamide, glimepiride, ciclosporin, olmesartan, ethinylestradiol (oral contraceptives)
•-Pregnancy or pregnancy planning

发起方

Medical Center Leeuwarden