Novel Coating to Minimize Bacterial Adhesions and Tooth Wear in Denture Acrylic

Completed

• Conditions: Denture Stomatitis; Wear of Denture Teeth
• Interventions: Device: PECVD coating

• Registration Number: NCT02834832
• Lead Sponsor: University of Florida

Brief Summary

This study evaluates the effect of coatings on bacterial adhesion on denture acrylic and the wear of denture teeth.

Detailed Description

Denture stomatitis is a prevalent disease among removable denture wearers. The cause of this disease stems from a myriad of factors including host immunity and poor oral hygiene. Denture acrylic material is very conducive for the growth and adhesion of bacteria because of its porous nature. The application of plasma enhanced chemical vapor deposited (PECVD) coatings on the surface of acrylic dentures can produce a less porous surface which may minimize the adhesion of bacteria and therefore colonization. The goal is the application of these coatings will help minimize the occurrence of denture stomatitis.

Another issue of removable dentures is the low wear resistance of denture teeth. The application of these coatings on denture teeth should minimize wear of these teeth and prolong the life of removable dentures.

Study Timeline

• Study First Submitted: 2016-06-30
• Study First Submitted QC: 2016-07-12
• Study First Posted: 2016-07-15
• Study Start: 2016-11
• Primary Completion: 2019-07-18
• Study Completion: 2019-07-18
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-21
• Last Update Posted: 2020-07-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• Patients who are missing some teeth and will need removable dentures

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Exclusion Criteria

• Medical contraindication for dental treatment

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PECVD Coatings	PECVD coating	The patients will be given removable partial dentures with PECVD coatings on both the tissue surface of the dentures and the acrylic denture teeth.

Primary Outcome Measures

Name	Time	Method
Change in Bacterial Count	2,4 and 12 weeks	Biofilms on the tissue surface of the dentures will be obtained for the aforementioned time intervals. Biofilm counts will be analyzed to determine the effect of the coatings on the number of disease causing bacteria on the surface of the denture

Secondary Outcome Measures

Name	Time	Method
wear of denture teeth	6 months	Denture teeth will be analyzed for wear at 6 months to determine the effect of PECVD coatings on the wear of denture teeth.

Trial Locations

Locations (1)

University of Florida; 🇺🇸 Gainesville, Florida, United States